微波照射肺俞穴联合干扰素雾化吸入治疗小儿肺炎临床研究

Clinical Study on Microwave Irradiation at Feishu Point Combined with Aerosol Inhalation of Interferon for Pneumonia in Children

目的:观察微波照射肺俞穴联合干扰素雾化吸入治疗小儿肺炎的临床疗效及其对血清炎症因子的影响。方法:将112例小儿肺炎患者随机分为对照组和观察组,各56例;对照组给予重组人干扰素α1b雾化吸入治疗,观察组在对照组基础上加用微波照射肺俞穴治疗,疗程均为7 d;观察比较2组临床疗效及不良反应情况,治疗后患儿咳嗽、喘息、湿啰音消失时间及住院时间,治疗前后患者肺功能及炎症因子水平变化。结果:总有效率观察组为92.86%,对照组为76.79%,2组比较,差异有统计学意义(P<0.05)。治疗后,观察组患儿咳嗽、喘息、湿啰音消失时间及住院时间均短于对照组,2组比较,差异有统计学意义(P<0.05)。治疗后,2组患者C-反应蛋白(CRP)、白细胞介素-6 (IL-6)、肿瘤坏死因子-α(TNF-α)水平均较治疗前明显降低(P<0.05),且观察组上述指标均明显低于对照组(P<0.05)。治疗后,2组患者呼气高峰流速(PEFR)、最大通气量(MVV)较治疗前明显增高(P<0.05),气道阻力(Raw)较治疗前明显降低(P<0.05);且观察组上述指标改善明显优于对照组(P<0.05)。不良反应发生率观察组为3.57%;对照组为14.29%,2组比较,差异无统计学意义(P>0.05)。结论:微波照射肺俞穴联合重组人干扰素雾化吸入治疗小儿肺炎疗效显著,可明显改善呼吸功能、减轻症状,改善炎症因子水平,抑制机体炎症反应,且安全性较高。

Objective:To observe the clinical effect of microwave irradiation at Feishu point(BL 13) combined with aerosol inhalation of interferon for pneumonia in children,and its effect on inflammatory factors in serum. Methods:A total of 112 cases of children with pneumonia were randomly divided into the control group and the observation group,56 cases in each group. The control group was given aerosol inhalation of recombinant human interferon α1 b,and the observation group was additionally given microwave irradiation at Feishu point based on the treatment of the control group. Both groups were treated for seven days. The clinical effect and adverse reactions,the disappearance time of cough,wheezes and moist rales as well as hospitalization time after treatment,and the changes of the lung function and levels of inflammatory factors before and after treatment in the two groups were observed and compared. Results: The total effective rate was 92.86% in the observation group and 76.79% in the control group, the difference being significant(P<0.05). After treatment, the disappearance time of cough,wheezes and moist rales as well as hospitalization time in the observation group were shorter than those in the control group,the difference being significant(P<0.05). After treatment,the levels of C-reactive protein(CRP), interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) in the two groups were obviously decreased when compared with those before treatment(P<0.05),and the above levels in the observation group were obviously lower than those in the control group(P<0.05). After treatment,peak expiratory flow rate(PEFR) and maximal voluntary ventilation(MVV)in the two groups were obviously increased when compared with those before treatment(P<0.05),and airway resistance(Raw) was obviously decreased when compared with that before treatment(P<0.05);the improvement of the above indexes in the observation group was better than that in the control group(P<0.05). The incidence of adverse reactions was 3.57% in the observation group and 14.29% in the control group,there being no significance in the difference(P>0.05). Conclusion:The therapy of microwave irradiation at feishu point combined with aerosol inhalation of recombinant human interferon has significant curative effect in treating children with pneumonia,which can significantly improve respiratory function,reduce symptoms,improve levels of inflammatory factors and inhibit inflammatory response of the body with high safety.