摘要
糖尿病视网膜病变(diabetic retinopathy,DR)在糖尿病肾病(diabetic nephropathy,DN)人群,特别是终末期糖尿病肾病(end stage diabetic nephropathy,ESRD)患者中的发病率和严重程度明显高于糖尿病人群。其中ESRD的一项重要治疗手段——血液透析(Hemodialysis,HD)可能会增加机体氧化应激反应、出血风险以及视神经的缺血缺氧,加重DR的发生发展;但另一方面也可通过清除尿毒症毒素、控制血压以及清除多余体液等途径改善糖尿病和DN对眼部的损伤。
The incidence and severity of diabetic retinopathy(DR)in patients with diabetic nephropathy(DN),especially those with end-stage renal disease(ESRD),were higher than those with diabetes.Hemodialysis(HD),an important treatment of ESRD,may aggravate DR by increasing the oxidative stress,fundus hemorrhage and hypoxia of the optic nerve.On the other hand,HD can improve the ocular damage caused by diabetes mellitus and DN by removing uremia toxin,controlling blood pressure and removing excess body fluid.
作者
周虹利(综述)
张学东(审校)
ZHOU Hongli;ZHANG Xuedong(Department of Ophthalmology,the First Affiliated Hospital of Chongqing Medical University,Chongqing Eye Institute,Chongqing Key Laboratory of Ophthalmology,Chongqing 400010,China)
出处
《眼科学报》
2020年第1期43-47,共5页
Eye Science
基金
国家自然科学基金(81870673)。
