1~4岁孤独症患儿血清性激素水平变化的病例对照研究

A case-control study on serum sex hormone levels in autistic children aged 1-4 years

目的比较1~4岁孤独症儿童与正常儿童血清中性激素水平变化的差异,分析其临床意义。方法按照《精神疾病诊断与统计手册-第五版(DSM-Ⅴ)》,选取确诊的1~4岁孤独症儿童35例作为研究组,另外选择40例健康儿童作为对照组。采用化学发光免疫分析法测定两组儿童血清中孕酮(Progesterone,P)、雌二醇(Estradiol,E2)、睾酮(Testosterone,T)、促黄体生成素(Luteotropic hormone,LH)和卵泡刺激素(Follicle-stimulating hormone,FSH)水平并进行统计学分析。结果研究组孤独症患儿与对照组正常儿童血清性激素T水平分别为(0.16±0.06)ng/mL,(0.08±0.02)ng/mL;P水平分别为(0.10±0.03)ng/mL,(0.14±0.04)ng/mL,两组之间差异具有统计学意义(P<0.05);E2、LH、FSH等性激素水平等在两组之间差异的比较无统计学意义(P>0.05)。结论孤独症患儿血清P、E2、T、LH、FSH等性激素水平无性别差异。1~4岁孤独症患儿的血清性激素T水平较高,P水平较低,具有一定的临床意义。

Objective To compare the differences of serum sex hormone levels between autistic children and normal children(in 1~4 years old) and evaluate their clinical significance. Methods According to The diagnostic and statistical manual of mental illness-the fifth edition(DSM-Ⅴ), 35 children who were definitely diagnosed as autism were selected as a study group, and 40 normal children were selected as a control group. The levels of serum progesterone(P), estradiol(E2), testosterone(T), luteotropic hormone(LH) and follicle-stimulating hormone(FSH) in the two groups were determined by chemiluminescence immunoassay and the data were statistically processed. Results The average serum sex hormone T levels were(0.16±0.06) ng/mL of the study group and(0.08±0.02) ng/mL of the control group respectively, the average P levels were(0.10±0.03) ng/mL of the study group and(0.14±0.04) ng/mL of the control group respectively, and there were significant differences between the two groups(both P<0.05). There were no significant differences between two groups in the levels of E2, LH, FSH(all P>0.05). In the study group, there were no significant differences between different genders in the serum sex hormone levels(P>0.05). Conclusion The serum levels of P, E 2, T, LH, FSH and other sex hormones in autistic children are independent of gender factors. However, the changes of serum T and P levels may be correlated with the etiology and pathogenesis of autism, which is of certain clinical significance.