复方丹参滴丸联合单硝酸异山梨酯治疗冠心病心绞痛疗效和安全性分析

Efficacy and Safety of Compound Danshen Dropping Pills Combined with Isosorbide Mononitrate in Treatment of Angina Pectoris of Coronary Heart Disease

[目的]观察复方丹参滴丸联合单硝酸异山梨酯治疗冠心病心绞痛疗效和安全性分析。[方法]将96例冠心病心绞痛患者按随机数字表法分为对照组和观察组各48例。对照组单硝酸异山梨酯,20 mg,2次/d。治疗组加用复方丹参滴丸,10丸/次,3次/d。治疗2个月,观测治疗有效率、血液流变学指标、不良反应。[结果]治疗后,总有效率观察组93.75%高于对照组79.17%;差异有统计学意义(P<0.05)。血液流变学指标观察组优于对照组,差异均有统计学意义(P<0.05)。不良反应发生率观察组10.42%,对照组12.50%,差异无统计学意义(P>0.05)。[结论]复方丹参滴丸联合单硝酸异山梨酯治疗冠心病心绞痛,可提高临床疗效,不增加不良反应发生率,值得推广。

[Objective]To observe the efficacy and safety of Compound Danshen Dropping Pills combined with isosorbide mononitrate in the treatment of angina pectoris of coronary heart disease.[Methods]A total of 96 patients with angina pectoris of coronary heart disease were divided into control group and observation group according to random number table method,48 cases in each group.The control group was treated with isosorbide mononitrate,20 mg twice a day.The treatment group was treated with Compound Danshen Dropping Pills,10 pills per time,3 times per day.After 2 months treatment,the effective rate,hemorheological parameters and adverse reactions were observed.Results:After treatment,the total effective rate of the observation group was 93.75%,higher than 79.17%of the control group,and the difference was statistically significant(P<0.05).The hemorheological indexes in the observation group were better than those in the control groupwith statistical significance(P<0.05).The incidence of adverse reactions was 10.42%in the observation group and 12.50%in the control group with no significant difference(P>0.05).[Conclusion]Compound Danshen Dropping Pills combined with isosorbide mononitrate in the treatment of angina pectoris of coronary heart disease can improve the clinical efficacy,without increasing the incidence of adverse reactions.It is worthy of promoting.