儿童大动脉炎1例报告

Takayasu’s arteritis in children:a case report

目的 探讨儿童多发性动脉炎发作的临床特点.方法 分析1例最终确诊为大动脉炎患儿的临床资料,并复习相关文献.结果 7岁女性患儿,反复不明原因发热,炎症指标均明显升高,抗感染治疗无效.行正电子发射计算机断层显像(PET-CT)考虑血管炎.给予糖皮质激素治疗后,病情出现反复,行血管造影明确大动脉炎诊断.随后予手术、糖皮质激素及环磷酰胺联合治疗,未再复发.结论 对于不明原因发热,伴炎症指标升高而抗感染治疗无效者,需警惕多发性动脉炎;早期行PET-CT,确诊后使用糖皮质激素及环磷酰胺联合治疗可有效改善预后.

Objective To explore the clinical characteristics of Takayasu’s arteritis in children.Method The clinical data of Takayasu’s arteritis in a child were analyzed,and the relevant literatures were reviewed.Results The 7-year-old girl had recurrent fever of unknown causes,and the inflammatory indicators were significantly increased,and the anti-infection treatment was ineffective.PET-CT was performed and vasculitis was considered.After receiving glucocorticoid therapy,the patient's condition was recurrent,and angiography was performed to confirm the diagnosis of arteritis.Subsequently,the patient had surgical operation,and treated with glucocorticoids and cyclophosphamide,and no recurrence occurred.Conclusions For those with unexplained fever,accompanied by elevated inflammatory indicators and ineffective anti-infective treatment,clinician should be alert to the possibility of Takayasu’s arteritis.Early PET-CT examination and treatment by combination of glucocorticoid and cyclophosphamide after diagnosis can effectively improve the prognosis.