淋巴细胞亚群在抑郁症发病过程中的作用

Role of lymphocyte subsets in pathogenesis of depression

抑郁症是当今社会发病率不断升高的一类精神疾病。随着抑郁症炎症假说不断发展,淋巴细胞亚群在抑郁症发病过程的作用受到了密切关注,但由于人们对许多淋巴细胞亚群的认知目前仍不够充分,且淋巴细胞亚群在不同抑郁时期的动态变化仍缺乏深入研究,完全解明淋巴细胞亚群在抑郁过程中的作用机制仍然十分艰巨。本文回顾了Th17、Th2、Treg、CD4+/CD8+T细胞和B细胞与抑郁症的相关研究进展,旨在为进一步阐明淋巴细胞亚群在抑郁症发病过程中的活动规律和作用机制提供参考资料,为新型抗抑郁药物的研发提供科学思路。

Depression is a kind of mental illness with increasing morbidity in modern society.With the continuous development of depression inflammation hypothesis,the role of lymphocyte subsets on the pathogenesis of depression is given a lot of attention.However,people′s knowledge on the lymphocyte subsets is still inadequate,and the data on the dynamic change of lymphocyte subsets in different depression period is still incomplete,therefore at present,it is very difficult to fully unriddle the mechanism of lymphocyte subsets in the pathogenesis of depression.This paper reviews the research progress of Th17,Th2,Treg,CD4+/CD8+T cell and B cell related to depression,and aims to provide references for further elucidation of the activity rules and mechanism of lymphocyte subsets in the pathogenesis of depression and supply scientific ideas for the development of new antidepressants.