中老年女性血清25羟维生素D水平与骨密度、体质量指数的调查研究

A study on the relationship of serum 25-hydroxyvitamin D levels,bone mineral density and body mass index in middle-aged and elderly women

目的调查深圳市中老年女性人群血清25羟维生素D水平、骨密度(bone mineral density,BMD)和体质量指数(body mass index,BMI)并探讨其相关性,为骨质疏松症(osteoporosis,OP)的防治提供相应的依据。方法收集2018年10月至2019年2月于深圳平乐骨伤科医院(坪山区中医院)参与调查的中老年女性212例[年龄50~84岁,平均(60.1±7.8)岁],测量受试者的身高、体重,计算BMI,根据BMI分成体重过低组(6例)、正常体重组(112例)和超重组(94例),分别测量各组骨密度和血清25羟维生素D水平。采用Spearman相关分析观察指标间的相关性。结果体重过低组、正常体重组和超重组三组的OP患病率依次为:83.3%、58.0%和57.4%,三组的差异不具有统计学意义(P>0.05)。正常体重组的25羟维生素D与BMD、BMI均不存在相关关系(P>0.05),BMD与年龄的关系呈负相关,与身高、体重均呈正相关(P<0.05),但是与BMI之间则不存在相关性(P>0.05)。在超重组中,25羟维生素D与BMI呈负相关,BMD与年龄呈负相关,与身高呈正相关(P<0.05),但是与体重、BMI之间的相关性无统计学意义(P>0.05)。结论在BMI正常范围内,高体重是OP的保护因素,而超重时则不存在此关系。且超重对中老年女性的血清25羟维生素D水平可产生负面影响。过重的体重可能不利于OP的防治,中老年女性应控制体重在正常范围内。

Objective To investigate serum 25-hydroxyvitamin D levels,bone mineral density(BMD)and body mass index(BMI)in middle-aged and elderly women in Shenzhen city and to explore their correlations,so that corresponding evidence can be provided for the prevention and treatment of osteoporosis(OP).Methods A total of 212 middle-aged and elderly females(aged50-84 years old,average 60.11±7.84 years)from Shenzhen city,participated in the survey in our hospital from October 2018 to February 2019.Their height and weight measured,BMI calculated,and were divided into three groups according to BMI:the underweight group(6 cases),the healthy weight group(112 cases),and the overweight group(94 cases).Then their BMD and serum 25-hydroxyvitamin D levels were examined separately.Spearman correlation was used to analyze the relative relationship between the indicators.Results The prevalence of OP among the three groups were 83.3%,58.0%and 57.4%,respectively,and the difference among the groups was not statistically significant(P>0.05).In healthy weight group,there was no compelling correlation among 25-hydroxyvitamin D,BMD and BMI(P>0.05).BMD showed a negative correlation with age,a favorable correlation with height and weight(P<0.05),while no correlation with BMI(P>0.05)in this group.In overweight group,25-hydroxyvitamin D was negatively correlated with BMI.There existed negative correlation between BMD and age,and positive correlation between BMD and height(P<0.05).No significant correlation was observed among BMD,weight and BMI(P>0.05)in this group.Conclusion High body weight is a protective factor for OP in the normal range of BMI,while there is no correlation when overweight.Overweight can have a negative impact on serum 25-hydroxyvitamin D levels in middle-aged and elderly women.Excessive weight may not be conducive to the prevention and treatment of OP,and middle-aged and elderly women should control their body weight within the normal range.