健康中年人血清炎症标志物与骨密度的相关性研究

Correlation between serum inflammation markers and bone mineral density in healthy middle-aged adults

目的探讨健康中年人血清C反应蛋白(CRP、脂联素、肿瘤坏死因子-α(TNF-α)与骨密度之间相关性。方法我们测量了76名成人的血清CRP、脂联素、TNF-α以及腰椎和股骨颈骨密度(BMD)并分析之间相关性。结果按照BMD检测结果将76名参与者分为两组:BMD正常组(40,52.6%),和BMD降低组(36,47.4%)。BMD降低组CRP较BMD正常组水平显著升高,差异有统计学差异(P<0.05)。BMD降低组的脂联素水平较低,但差异无统计学意义(P>0.05)。BMD降低组的TNF-α水平较高,差异无统计学意义(P>0.05)。Pearson相关系数分析显示BMD降低组的BMD与CRP呈负相关性。结论健康中年人血清CRP与BMD呈负相关性。

Objective The aim of this study was to investigate the correlation among serum C-reactive protein(CRP),adiponectin,tumor necrosis factor-α(TNF-α),and bone mineral density(BMD)in healthy middle-aged people.Methods Serum levels of CRP,adiponectin,TNF-α,and BMD of the lumbar spine and femoral neck were measured in 76 adults.Results76 participants were divided into two groups according to BMD result:BMD normal group(n=40,52.6%)and BMD reduction group(n=36,47.4%).CRP in the BMD reduction group was significantly higher than that in the normal BMD group,and the difference was statistically significant(P<0.05).The adiponectin concentration in the BMD reduction group was lower,but the difference was not significant(P>0.05).The concentration of TNF-αin the BMD reduction group was higher,but the difference was not statistically significant(P>0.05).Pearson coefficient correlation analysis showed that BMD in the BMD reduction group was negatively correlated with CRP.Conclusion Serum CRP is negatively correlated with lower BMD in healthy middle-aged people.