青娥丸对绝经后骨质疏松症患者骨密度、骨代谢指标和骨硬化蛋白的影响

Effect of Qinger pill on bone mineral density,bone metabolism index,and sclerostin in patients with postmenopausal osteoporosis

目的观察青娥丸(QEW)对绝经后骨质疏松症患者骨密度、骨代谢指标和骨硬化蛋白的影响。方法2016年1月至6月期间,我院收治的120例门诊和住院PMOP患者随机分为QEW组(给予钙片和青娥丸),ALF组(给予钙片和阿法骨化醇)和对照组(给予钙片)(每组n=40),随访期为1年。测量基线和治疗1年后血清骨硬化蛋白、25羟维生素D和骨转换标志物(β-CTX,N-MID和T-PINP)的水平。结果QEW组和ALF组治疗后1年血清骨硬化素水平显著高于对照组(P<0.05),但QEW组和ALF组比较差异无统计学意义(P>0.05)。治疗后1年QEW组和ALF组血清β-CTX,N-MID和T-PINP水平均降低,而两组间差异无统计学意义(P>0.05)。但QEW组和ALF组血清β-CTX,N-MID和T-PINP水平显著低于对照组(P<0.05)。结论QEW调节绝经后骨质疏松症患者骨代谢的机制可能与QEW增加硬化蛋白表达的作用有关。

Objective To observe the effect of Qinger pill(QEW)on bone mineral density,bone metabolism index,and sclerostin in patients with postmenopausal osteoporosis(PMOP).Methods A total of 120 outpatients and inpatients with PMOP treated in our hospital from January to June 2016 were randomly divided into QEW group(receiving calcium tablets and QEW pills),ALF group(receiving calcium tablets and alfacalcidol treatment),and control group(receiving calcium tablets,n=40 in each group).The follow-up period was 1 year.The serum levels of sclerostin,25-hydroxyvitamin D,and bone turnover markersβ-CTX,N-MID,and T-PINP at baseline and at the 1 st year after treatment were measured.Results The result showed that the levels of circulating sclerostin increased significantly at the 12 th month after treatment in QEW group and ALF group as compared with control group(P<0.05),but there was no significant difference between the former two groups(P>0.05).The serum levels ofβ-CTX,N-MID,and T-PINP decreased in both QEW group and ALF group at the 12 th month after treatment,without significant difference between the two groups(P>0.05).But the levels were significantly lower than that in control group(P<0.05).Conclusion The mechanism by which QEW modulates bone metabolism in patients with PMOP might be related to the effect of QEW on increasing sclerostin expression.