骨质疏松症中医证型现代化研究思路探索

Exploration of modernization of TCM syndrome type of osteoporosis

骨质疏松症(osteoporosis,OP)的发病率逐年上升,严重影响患者生活。中医药治疗OP具有优势,但限制其发展的是中医辨证客观化、规范化、标准化及现代化不足。本综述对OP中医证型现代化研究现状进行分析与评价,从中英文数据库中筛选文献,发现OP中医证型判别尚不统一;常用的OP现代化指标不能全面阐述"证"的实质。因而提出统一公认的中医证型是科学研究的基础,非编码RNA中LncRNA、miRNA以及组学技术等新兴技术可以为OP中医证型研究提供新思路和较全面的科学依据。联合多组学技术对OP中医证型的相关性研究、运用多组学技术检测中医药治疗OP中医具体证型的疗效研究以及OP肾虚证与LncRNA、miRNA、靶基因网状调控系统相关性研究是进一步探索的方向。

The incidence of osteoporosis(OP)is increasing year by year,seriously affecting the live of the patients.TCM treatment of OP has advantages,but its development is limited by the lack of objectivity,standardization,and modernization of TCM syndrome differentiation.This review analyses and evaluates the current research status of TCM syndrome modernization of OP.By screening the literatures from Chinese and English databases,it is found that the differentiation of TCM syndrome type of OP is not uniform.The commonly used OP modernization indicators can not fully elaborate the essence of"syndrome".Therefore,it is proposed that universally recognized TCM syndromes are the basis of scientific research.New technologies such as LncRNA,microRNA,and genomics in non-coding RNA can provide new ideas and more comprehensive scientific basis for TCM syndrome research of OP.It is the further study direction by combination of OP TCM syndromes with genomics technology,by application of the genomics technology to detect the efficacy of TCM in treating OP of different TCM syndromes,and by the correlation between kidney deficiency syndrome of OP and LncRNA,microRNA,target gene reticular regulatory system.