细胞内蛋白质降解:通过溶酶体和泛素--蛋白酶体系统探索人类疾病和药物靶向治疗的未来

Intracellular protein degradation:exploring the future of human disease and drug-targeted therapy through lysosomal and ubiquitin-proteasome systems

在真核细胞内主要存在两种蛋白降解系统,自噬-溶酶体系统和泛素-蛋白酶体系统(UPS),对维持蛋白稳态至关重要。本文综述了自噬-溶酶体系统和UPS的组成、功能、相互作用、功能相关性以及与肿瘤的关系,其作为药物靶标的可行性,对于未来肿瘤靶向药物的研制具有重要的指导作用,同时对于全面理解自噬-溶酶体系统和UPS的功能和机制也有重要的参考价值。

There are two main protein degradation systems in eukaryotic cells:autophagy-lysosome system and ubiquitin-proteasome system(UPS),which are essential to maintain protein homeostasis.This article reviews the composition,function,interaction,functional relevance of the autophago-lysosomal system and UPS,as well as the association with tumors,the feasibility as drug targets plays an important role in the future development of tumor-targeting drugs,and also has important reference value for a comprehensive understanding of the functions and mechanisms of the autophago-lysosome system and UPS.