使用OCT评估中心性浆液性脉络膜视网膜病变患者脉络膜厚度的变化

Evaluation of the changes in choroidal thickness in patients with central serous chorioretinopathy as measured by optical coherence tomography

目的:使用光谱域光学相干断层成像(SD-OCT)技术研究中心性浆液性脉络膜视网膜病变(CSCR)3mo后脉络膜厚度的变化。方法:前瞻性研究。共纳入60眼,20眼(平均年龄:33.65±5.24岁)典型急性单侧中心性浆液性脉络膜视网膜病变以及对侧正常眼,20眼为健康对照组。进行荧光素血管造影和OCT检查。测量中心凹下脉络膜厚度(SFCT),黄斑中心凹视网膜厚度(CMT),到中央凹和视网膜下液1000μm处颞部和鼻部。结果:在三个不同的位置,三组间的SFCT差异有统计学意义。中心性浆液性脉络膜视网膜病变眼中心凹下脉络膜厚度(372.40±34.39μm)在基线和随访3mo后均显著大于对侧正常眼(302.10±8.9μm)和对照组眼(279.80±14.49μm)。CSCR眼平均CMT为317±141.86μm,并且SFCT与CMT呈显著正相关。结论:不同部位脉络膜厚度的增加,以及被称为“厚脉络膜”的过度扩张和高渗透血管,似乎在包括中心性浆液性脉络膜视网膜病变在内的广泛疾病中起着重要作用。

AIM:To study the changes in choroidal thickness in central serous chorioretinopathy(CSCR)over a 3mo follow-up using spectral domain optical coherence tomography(SD-OCT).METHODS:This prospective study included 60 eyes,both eyes of 20 patients(mean age:33.65±5.24 years)with classic acute unilateral central serous chorioretinopathy and normal fellow eye and 20 eyes as healthy controls.Fluorescein angiography and OCT were done.The subfoveal choroidal thickness(SFCT),central macular thickness(CMT),1000μm temporal and nasal to the centre of the fovea and the subretinal fluid were measured.RESULTS:There was a statistically significant difference in SFCT among the three groups at the three different locations.SFCT in eyes with CSCR(372.40±34.39μm)was significantly greater than that in each of the unaffected fellow eyes(302.10±8.9μm)and control eyes(279.80±14.49μm)at the base line and after 3mo follow-up.The mean CMT in CSCR was 317±141.86μm,with a statistically significant positive correlation between SFCT and CMT.CONCLUSION:The increase in the choroidal thickness at different locations as well as hyper-dilated and hyper-permeable vessels known as“pachychoroid”seems to play an important role in a broad spectrum of diseases that includes central serous chorioretinopathy.