干眼症患者泪液炎症因子与症状体征相关性研究

Study on the correlation between tear inflammatory factors and symptoms in patients with dry eye

目的:观察干眼症患者泪液炎症因子白细胞介素-1β(IL-1β)和白细胞介素-18(IL-18)与症状体征的相关性。方法:选取2018-09/12在湖南中医药大学第一附属医院眼科干眼门诊就诊的患者131例262眼,根据2013年干眼临床诊疗专家共识中干眼的分级标准将患者分为无干眼组、轻度干眼组、中度干眼组、重度干眼组,检测所有患者干眼症状评分、泪膜破裂时间(BUT)、泪液分泌试验(SⅠt)、角膜荧光素钠染色评分(FL)的情况,ELISA法检测患者泪液中IL-1β、IL-18的表达,分析干眼炎症因子与症状体征的相关性。结果:各组患者干眼症状评分、BUT、SⅠt、FL及泪液中IL-1β、IL-18表达差异均有统计学意义(P<0.001),炎症因子IL-1β、IL-18与干眼症状评分、FL呈正相关(P<0.05),与BUT、SⅠt呈负相关(P<0.05)。结论:干眼患者泪液中炎症因子与干眼症状体征具有相关性。

AIM:To observe the correlation between the interleukin-1β(IL-1β)and interleukin-18(IL-18)in tears of patients with dry eye and symptoms and signs.METHODS:A total of 131 patients(262 eyes)who were treated for dry eye in the ophthalmology clinic of the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine were selected from September 2018 to December 12,and the patients were divided into dry eye classification standards according to the dry eye clinical consensus in 2013 No dry eye group,mild dry eye group,moderate dry eye group,severe dry eye group.All patients were examined for dry eye symptom score,break up time(BUT),and tear secretion test Schirmer I test(SⅠt),corneal fluorescein sodium staining(FL),ELISA method to detect the expression of IL-1βand IL-18 in tears,and to analyze the correlation between dry eye inflammatory factors and symptoms and signs.RESULTS:There were significant differences in the expression of dry eye symptoms,BUT,SⅠt,FL and IL-1βand IL-18 in tears(P<0.001),inflammatory factors IL-1β,IL-18 and dry eye symptom scores.FL was positively correlated(P<0.05)and negatively correlated with BUT and SⅠt(P<0.05).CONCLUSION:Inflammatory factors in tears of dry eye patients were correlation with dry eye symptom and signsa.