妇女产褥期感染对血清细胞因子与氧化应激指标的影响

Impact of puerperal infection on serum cytokines and oxidative stress indexes

目的探究产妇产褥期感染对血清细胞因子与氧化应激指标的影响。方法选取2015年6月-2018年9月于日照市妇幼保健院接受治疗的64例产褥期感染产妇作为研究组,另选同期60例健康产妇作为对照组。检测并比较两组血清细胞因子和氧化应激指标水平,比较不同类型感染产妇的血清细胞因子和氧化应激指标水平。结果研究组IL-6(12.43±1.42)mg/L、IL-8(11.46±1.22)mg/L、CRP(3.52±0.26)mg/L、PCT(1.48±0.32)μg/L水平均高于对照组(P<0.05),研究组抗凝血酶Ⅲ水平(70.69±5.37)%低于对照组(79.64±0.45)%,两组比较差异有统计学意义(P<0.05);研究组总抗氧化能力(7.86±0.31)kU/L、超氧化物岐化酶水平(71.32±6.49)nU/ml低于对照组(P<0.05),丙二醛(3.27±0.38)nmol/ml以及髓过氧化物酶水平(3.12±0.48)ng/L均高于对照组(P<0.05);产褥感染产妇中以子宫内膜炎和输卵管炎较为常见,不同感染类型血清细胞因子和氧化应激指标比较差异有统计学意义(P<0.05)。结论血清细胞因子和氧化应激指标水平对于产褥感染类型具有重要鉴别意义,有助于临床医务人员对产妇感染情况和严重情况进行简单判断,并采取相关治疗措施。

OBJECTIVE To explore the impact of puerperal infection on serum cytokines and oxidative stress indexes. METHODS A total of 64 puerpera with puerperal infection who were treated in Rizhao Maternal and Child Health Hospital from Jun 2015 to Sep 2018 were assigned as the study group, meanwhile, 60 healthy puerpera were set as the control group.The levels of serum cytokines and oxidative stress indexes were detected and compared between the two groups, and the levels of serum cytokines and oxidative stress indexes were compared among the puerpera with different types of infections. RESULTS The levels of IL-6, IL-8, CRP and PCT of the study group were respectively(12.43±1.42)mg/L,(11.46±1.22)mg/L,(3.52±0.26)mg/L and(1.48±0.32)μg/L, significantly higher than those of the control group(P<0.05).The antithrombin Ⅲ level of the study group was(70.69±5.37)%, significantly lower than(79.64±0.45)% of the control group(P<0.05).The total antioxidant capacity and superoxide dismutase level of the study group were respectively(7.86±0.31) kU/L and(71.32±6.49) nU/ml, significantly lower than those of the control group(P<0.05), the levels of malondialdehyde and myeloperoxidase of the study group were respectively(3.27±0.38)nmol/ml and(3.12±0.48)ng/L, significantly higher than those of the control group(P<0.05).The puerpera who had endometritis and salpingitis were dominant among the puerpera with puerperal infection, and there were significant differences in the serum cytokines and oxidative stress indexes among the puerpera with different types of infection(P<0.05). CONCLUSION The serum cytokines and oxidative stress indexes have great significance in differential diagnosis of the puerperal infection, which may facilitate the health care workers′ judgement on prevalence and severity of the infection so as to take relevant treatment measures.