耳念珠菌感染研究进展

Candida auris infection and progress of research

耳念珠菌(Candida auris)是一种新型的多重耐药真菌,它能引起侵袭性感染,病死率高,用传统的酵母菌鉴定方法难以识别。2009年首次在日本发现,后陆续在全球各地相继被报道。耳念珠菌可定植于患者皮肤,在环境中持续存在,并在患者间进行传播,造成医院感染的暴发。预防和控制耳念珠菌的传播需要公共卫生机构的通告、接触预防措施的落实、彻底的环境清洁与消毒、感染控制的评估、追踪接触者及筛查定植者,是微生物记录的回顾性分析及病例的前瞻性监测。本文对目前世界上耳念珠菌感染的流行、耐药性、毒力及推荐的预防与控制方法进行综述。

As a newly emerging multidrug-resistant fungus, Candida auris can cause invasive infections, with the mortality rate high.It is difficult to identify it by traditional yeast identification methods.It was first discovered in Japan in 2009 and has been successively reported around the world.C.auris can colonize the skin of patients, persistently exist in the environment, and spread among patients, resulting in outbreaks of nosocomial infections.The prevention and control of the spread of C.auris requires public health notification, implementation of contact prevention measures, thorough environmental cleaning and disinfection, evaluation of infection control, tracking of contacts, screening of colonizers and retrospective analysis of microbiological records as well as prospective surveillance of cases.The current epidemic, drug resistance, virulence and recommended methods for prevention and control of C.auris infection in the world are reviewed in the article.