新型冠状病毒肺炎重症患者救治的华山模式及其临床意义

The “Huashan model” for Treating Patients with Severe NCP Infected with COVID-19 and Its Clinical Significance

重症新型冠状病毒肺炎(NCP)患者约占全部COVID-19确诊感染患者15%,尽管按照指南要求对重症患者进行重症监护室(ICU)收治,但目前尚无针对COVID-19的特效药物,因此重症患者病死率仍然较高。根据本次疫情中重症患者的临床表现,复旦大学附属华山医院提出COVID-19感染重症NCP患者救治的"华山模式",即以支持治疗为核心,早期使用糖皮质激素控制炎症,联合丙种球蛋白中和毒素,并给予预防性抗凝治疗。该文介绍"华山模式"所涉及的四个方面治疗措施及其原理,其目的是为COVID-19感染的重症NCP患者有效救治提供治疗思路和参考依据。

Patients with severenovel coronavirus pneumonia(NCP)account for approximately 15% of all confirmed cases of 2019 novel coronavirus disease(COVID-19)infection.Currently,patients with severe NCP are all treated in the intensive care unit(ICU)according to guidelines.Becausethere are currently no specific drugsthat specifically target COVID-19,the mortality of patients with severe NCP is still high.Based on the clinical manifestations of patients with severe NCP in this outbreak,Huashan Hospital affiliated with Fudan University proposed the "Huashan model" for the treatment of patients with severe NCP infected with COVID-19: supportive therapy is the core,combined with the early use of high-dose glucocorticoid to control inflammation, intravenous immunoglobulin(IVIG)therapy to neutralize toxins, and preventive anticoagulant therapy.This paper introduces the four treatments used in the "Huashan model" and their mechanisms, in order to provide treatment options and a reference for the effective treatment of patients with severe NCP infected with COVID-19.