母亲月经不调与早产儿视网膜病变发生的关系

Relationship between Maternal Irregular Menstruation and Retinopathy of Prematurity

目的探讨母亲月经不调与早产儿视网膜病变(retinopathy of prematurity,ROP)发生的关系。方法收集2019年1-3月在南昌大学附属眼科医院行ROP筛查的26例早产儿(其中5例为双胎)病例,对其母亲进行问卷调查及电话回访。根据常见的月经不调表现,取前5位相关因素(先兆流产、白带异常、月经来潮时间、月经量及痛经程度)作为研究参数,对各因素进行量化评分,并分析各因素与ROP发生的关系。结果26例母亲中,ROP早产儿母亲19例,无ROP早产儿母亲7例。ROP患儿母亲痛经程度[(4.37±2.11)分]高于无ROP早产儿母亲[(2.14±1.68)分](P<0.05);ROP早产儿母亲有先兆流产的概率[(1.74±0.45)分]高于无ROP早产儿母亲[(1.29±0.49)分](P<0.05);与无ROP早产儿母亲[(1.43±0.53)分]相比,ROP早产儿母亲月经量[(2.16±0.83)分]更不稳定(P<0.05);与无ROP早产儿母亲[(1.43±0.79)分]相比,ROP早产儿母亲月经来潮时间[(2.47±1.22)分]更不稳定(P<0.05);而ROP早产儿母亲与无ROP早产儿母亲白带异常评分比较差异无统计学意义(P>0.05)。结论母亲月经不调与ROP的发生之间存在一定的关联。月经不调作为一种症状体现,可能是胎儿疾病发生的一个影响因素。

Objective To explore the relationship between maternal irregular menstruation and retinopathy of prematurity(ROP).Methods Data of 26 premature infants who underwent ROP screening in the Affiliated Eye Hospital of Nanchang University from January 2019 to March 2019 were collected(including five pairs of twins).Their mothers were interviewed by questionnaire and telephone.According to the common performance of irregular menstruation,the top five related factors were taken as the research parameters,including threatened miscarriage,abnormal leucorrhea,menstrual duration,amount of menstrual bleeding and degree of dysmenorrhea.Quantitative analysis of the five related factors were performed to investigate the relationship between maternal irregular menstruation and ROP.Results Among the 26 cases,19 had ROP and 7 had not POR.The degree of dysmenorrhea,probability of threatened abortion,duration of menstrual bleeding and amount of menstrual bleeding significantly increased in the mothers of ROP infants((4.37±2.11),(1.74±0.45),(2.16±0.83) and(2.47±1.22),respectively),compared with the mothers of infants without ROP((2.14±1.68),(1.29±0.49),(1.43±0.53) and(1.43±0.79),respectively)( P<0.05).There was no significant difference in abnormal leukorrhea between the two groups(P>0.05).Conclusion There is a relationship between maternal irregular menstruation and infant ROP.As a symptom,irregular menstruation may be a related factor for fetal disease.