肝内胆管癌的流行病学特征及危险因素研究进展

Epidemiological characteristics and risk factors of intrahepatic cholangiocarcinoma

与肝门部胆管癌和肝外胆管癌相比,肝内胆管癌是一种少见的胆管恶性肿瘤,它具有独特的临床病程和流行病学特征。全世界范围内,肝内胆管癌的发病率具有很大的地域性差异,且整体发病率呈上升趋势。尽管目前已经确定了几个危险因素,如胆道疾病、感染因素等等,但许多患者并无明确的危险因素。现将其流行病学及发病危险因素作一综述。

Intrahepatic cholangiocarcinoma(ICC) is a rare cholangiocarcinoma with a distinct clinical course and epidemiology from hilar and extrahepatic cholangiocarcinoma.The incidence of ICC remains a considerable amount of geographic variation worldwide.Besides,the overall incidence of this malignancy appears to be rising.Several risk factors have been identified,such as biliary tract disease,infectious causes and so on.Despite this,a substantial number of ICC patients do not have any identifiable risk factors.This article will briefly introduce the research progress of epidemiological characteristics and risk factors of intrahepatic cholangiocarcinoma.