P-选择素在血栓形成中的作用及P-选择素抑制剂的研究进展

Role of P-selectin in thrombosis and research progress of P-selectin inhibitors

血栓性疾病是人类的主要健康问题,缩短患者生存时间,影响患者生存质量。当心血管内膜损伤、血流或血液性质改变时会诱发血栓形成,按其形成部位可分为动脉血栓和静脉血栓。研究者们发现P-选择素在两种血栓的形成过程中都发挥着重要的作用,可以通过三条途径促进血栓形成。多年来科研工作者们设计了诸多类型的P-选择素抑制剂,根据机制可归纳为下调P-选择素表达类型和与P-选择素活性中心特异性结合类型,研究表明它们可以抑制血小板聚集、动脉血栓和静脉血栓形成,同时加速血栓的溶解。

Thrombosis is a major health problem in the world.It can shorten the survival time of patients and affect their life quality.Thrombosis can be induced when cardiovascular intimal injuries and blood flow or blood properties changes.Thrombosis can be divided into arterial thrombosis and venous thrombosis according to the site of formation.Researchers have found that P-selectin plays an important role in the formation of two types of thrombosis,and promotion of thrombosis in three ways.Over the years,researchers had designed many types of P-selectin inhibitors,according to the mechanism which could be divided into the down-regulation of P-selectin expression and the specific binding with P-selectin active center.These P-selectin inhibitors proved to inhibit platelet aggregation,arterial thrombosis and venous thrombosis,and accelerate thrombolysis at the same time.