摘要
临床药师结合血药浓度、代谢酶基因型及感染、肝肾功能指标变化,协助医师对1例骨髓增生异常综合征异基因造血干细胞移植术后患者的抗感染和抗移植物抗宿主病药物治疗方案进行调整,在感染和移植物抗宿主病得到及时控制的同时,避免了因药物不良反应而影响关键治疗,有效促进了患者安全合理用药。
Clinical pharmacists assisted doctors to adjust the anti-infection and Graft versus host disease prophylactic regimen of a patient with myelodysplastic syndromes after allogeneic haematopoietic stem cell transplantation.Based on drug concentration in the plasma,metabolic enzyme genotype as well as the level changes in infection indicators,hepatic and renal function biomarkers.Pharmacists helped timely control the infection and Graft versus host disease,and therapy was performed without interruption by adverse reactions,effectively promoting rational use of drugs.
作者
林嘉贞
杨隽
吴佳琪
高君伟
LIN Jia-zhen;YANG Jun;WU Jia-qi;GAO Jun-wei(Department of Clinical Pharmacy,Shanghai General Hospital,Shanghai Jiao Tong University,Shanghai 200080;Department of Pharmacy,Xiang'an Hospital of Xiamen University,Xiamen Fujian 361000;Department of Hematology,Shanghai General Hospital,Shanghai Jiao Tong University,Shanghai 200080)
出处
《中南药学》
CAS
2020年第2期287-291,共5页
Central South Pharmacy
基金
上海市科委医学引导类(西医)科技支撑项目(No.194119698001)。
关键词
治疗药物监测
代谢酶基因型
免疫抑制
抗感染
造血干细胞移植
therapeutic drug monitoring
metabolic enzyme genotype
immunosuppression
anti-infection
hematopoietic stem cell transplantation
