脂肪肝严重程度与中医证型关系的Meta分析

The Relationship Between the Fatty Liver Severity and the TCM Syndromes:A Meta-Analysis

目的:分析脂肪肝轻中重度分型与中医证型分型之间的关系。方法:计算机检索中国期刊全文数据库(CNKI)、维普中文科技期刊数据库(VIP)、万方数据知识服务平台、中国生物医学文献数据库(CBM)。采用R-3.5.1软件进行Meta分析,以率、95%可信区间(CI)表达效应值。结果:共纳入12项观察性研究,样本量总计3379例。Meta分析结果:肝郁脾虚型中,轻度脂肪肝高于中、重度脂肪肝;痰湿内阻中,中度脂肪肝高于轻、重度脂肪肝;湿热内蕴中,轻度脂肪肝高于中、重度脂肪肝;痰瘀互结中,重度脂肪肝高于轻、中度脂肪肝;肝肾亏虚型无统计学差异。结论:基于目前证据,轻度脂肪肝以肝郁脾虚型及湿热内蕴型为主,中度脂肪肝以痰湿内阻型为主,重度脂肪肝以痰瘀互结型为主,肝肾亏虚型无统计学差异,其在脂肪肝分型中的分布情况需要更大的样本进一步验证。

Objective:To analyze the relationship between the mild,moderate and severe fatty liver and the TCM syndromes.Methods:The database of CNKI,VIP,Wanfang Data,CBM were retrieved.Meta-analysis was conducted with R-3.5.1 software having rate and 95%confidence interval(CI)as effect size.Results A total of 12 observation studies were included,involving 3379 total sample cases.Meta-analysis showed that in syndrome of stagnation of liver qi and spleen deficiency type,the mild was higher than moderate or severe;Among the syndrome of internal retention of damp-heat,mild was higher than moderate or severe;Among the syndrome of intermin-gled phlegm and blood stasis,severe was higher than mild and moderate;There was no statistical difference in the syndrome of deficiency of both liver and kidney type.Conclusion:Based on current evidence,light fatty liver was the stagnation and blockade of phlegm-damp type and internal retention of damp-heat type,and the moderate fatty liver was syndrome of stagnation and blockade of phlegm-damp type.Severe fatty liver was mainly the syndrome of intermin-gled phlegm and the syndrome of blood stasis type and syndrome of deficiency of both liver and kidney type,with no statistical difference.