通腑泻肺化痰法联合阿奇霉素序贯治疗肺炎支原体感染的临床效果观察

Effects of Tongfu Xiefei and Huatan Method Combined with Azithromycin Sequential Treatment on Patients with Mycoplasma Pneumoniae Infection

目的:通腑泻肺化痰法联合阿奇霉素序贯治疗对肺炎支原体感染患者血清IFN-γ、IL-1β、PCT水平的影响。方法:选取2017年10月至2018月10月北京中医药大学房山医院收治的肺炎支原体感染患者128例作为研究对象,按照随机数字表法将患者分为对照组和观察组,每组64例。对照组患者在常规退热、止咳、抗炎的基础上,采用阿奇霉素序贯抗感染治疗。观察组患者在对照组治疗的基础上口服通腑泻肺化痰汤治疗。2组均治疗2周。比较2组治疗疗效,治疗前后中医症候、体征积分,比较2组患者主症消失时间和住院时间,比较2组治疗前后临床炎性反应因子,比较2组治疗过程中的不良反应发生情况。结果:观察组治疗总有效率为92.19%,显著高于对照组的78.13%(P<0.05);观察组治疗后中医症候、体征积分低于对照组(P<0.05);观察组退热时间、痰壅消失时间、咳嗽消失时间、肺部啰音消失时间和住院时间均低于对照组(P<0.05);观察组治疗后血清炎性反应因子IFN-γ、IL-1β和PCT含量低于对照组(P<0.05);观察组不良反应发生情况低于对照组(P<0.05)。结论:通腑泻肺化瘀法治疗肺炎支原体感染疗效确切,可有效的改善患者的临床症候,缩短临床病程,降低炎性反应,和阿奇霉素联合应用,可提高治疗效果,且不良反应少,值得临床推广应用。

Objective:To observe the effects of Tongfu Xiefei and Huatan method combined with azithromycin sequential treatment on serum levels of IFN-γ,IL-1βand PCT in patients with mycoplasma pneumoniae infection.Methods:According to random number table method,a total of 128 patients in Fangshan Hospital,Beijing University of Chinese Medicine with mycoplasma pneumoniae infection were selected and divided into an observation group and a control group,wit 64 cases in each group.Patients in control group received azithromycin sequential anti-infective therapy on the basis of routine antipyretic,antitussive and anti-inflammatory treatment.The observation group was treated with Tongfu Xiefei Huatan Decoction based on the control group.Both groups were treated for 2 weeks.The curative effects of the 2 groups before and after treatment,which includes the scores of TCM symptoms and signs,time of main symptoms disappearance and hospitalization,clinical inflammatory factors,and the occurrence of adverse reactions during the treatment,were compared.Results:The total effective rate of the observation group was 92.19%,which is significantly higher than that of 78.13%in the control group(P<0.05).The scores of TCM symptoms and signs in the observation group were lower than those in the control group(P<0.05).The time of fever relieve,phlegm dissipating,cough disappearance,lung rale disappearance and hospitalization in the observation group were lower than those in the control group(P<0.05).The levels of serum inflammatory factors IFN-γ,IL-1βand PCT in the observation group were lower than those in the control group(P<0.05),and the incidence of adverse reactions in the observation group was lower than the other group(P<0.05).Conclusion:Tongfu Xiefei and Huayu method is effective in treating mycoplasma pneumoniae infection.It could improve the clinical symptoms effectively,shorten the disease course,and reduce inflammation reaction.Combined with azithromycin,it could enhance the effect,and have less adverse reactions,which is worthy of clinical promotion and application.