丹七胶囊对血小板聚集功能影响的临床研究

The influence of Danqi Capsule on platelet aggregation function

目的通过研究丹七胶囊对血小板聚集功能的影响,探讨丹七胶囊影响血小板聚集功能的生理机制。方法32名健康志愿者随机均分为空白对照组和低剂量、高剂量和超高剂量组,3个剂量组连续口服丹七胶囊(空白对照组服用安慰剂)1周,每日3次,于服药1周后采集空腹静脉血,检测血常规、凝血常规、生化常规和血小板最大聚集率(MA),诱导剂分别为二磷酸腺苷(ADP)、肾上腺素(EPI)、花生四烯酸(AA)、瑞斯托霉素(RIS)。结果服药1周后,3个剂量组的血常规、凝血常规、生化常规指标比较差异均无统计学意义(P>0.05)。高剂量组和超高剂量组中ADP和EPI诱导的MA较空白对照组下降,差异有统计学意义(P<0.05)。结论丹七胶囊可降低ADP和EPI诱导的血小板聚集功能,其可能通过抑制血小板腺苷酸环化酶活性发挥其抗血小板作用。

Objective To study the effect of Danqi Capsule on platelet function in healthy people.Methods 32 healthy volunteers were randomly divided into blank control group(placebo),low dose,high dose and ultrahigh dose group and medicines were taken orally consecutively in one week,three times per day.Fasting venous blood was measured for complete blood count,coagulation test,biochemical test and platelet maximum aggregation rate(MA)induced by adenosine diphosphate(ADP),epinephrine(EPI),arachidonic acid(AA)and ristomycin(RIS),after 1 week medication.Results After 1 week medication,there were no statistically significant differences in complete blood count test,coagulation test and biochemical test among three dose groups(P>0.05).The maximum platelet aggregation rate induced by ADP and EPI in the high-dose group and the ultra-high-dose group decreased compared with the blank control group,and the difference was statistically significant(P<0.05).Conclusion Danqi Capsule inhibit platelet aggregation and it may inhibit common pathway of ADP and EPI induced platelet aggregation.