GPC-3、CD147、CD10、CD138在肝细胞肝癌中的表达及临床意义

Expressions and clinical significance of GPC-3,CD147,CD10 and CD138 in hepatocellular carcinoma

目的探究磷脂酰肌醇蛋白多糖-3(GPC-3)、白细胞分化抗原147(CD147)、白细胞分化抗原10(CD10)、多配体蛋白聚糖-1(又名CD138)在肝细胞肝癌(HCC)中的表达及临床意义。方法收集2014年1月至2018年12月该院行手术治疗并经术后病理证实的HCC患者肝癌组织标本120例及癌旁组织(距癌灶边缘2 cm)标本120例,行免疫组化检测,比较GPC-3、CD147、CD10、CD138在肝癌组织及癌旁组织中的表达,并分析其与肿瘤分化程度的关系。结果GPC-3、CD147、CD10在肝癌组织中的阳性率显著高于癌旁组织,CD138在肝癌组织中的阳性率显著低于癌旁组织,差异有统计学意义(P<0.05);高分化组GPC-3、CD147、CD10阳性率显著低于中低分化组,高分化组CD138阳性率显著高于中低分化组,差异有统计学意义(P<0.05)。结论GPC-3、CD147、CD10、CD138表达水平可能与HCC的发生发展相关,或可将其作为肿瘤标志物,进一步指导HCC的临床诊断及鉴别。

Objective To explore the expressions and clinical significance of glypican-3(GPC-3),cluster of differentiation 147(CD147),cluster of differentiation 10(CD10)and syndecan-1(also known as CD138)in hepatocellular carcinoma(HCC).Methods 120 HCC tissues specimens and 120 adjacent tissues specimens(2 cm from the margin of foci)of HCC patients who were treated by surgery and confirmed by postoperative pathology from January 2014 to December 2018 were collected in a hospital and were given immunohistochemical detection.The expressions of GPC-3,CD147,CD10 and CD138 were compared in HCC tissues and adjacent tissues,and their relationship with tumor differentiation were analyzed.Results The positive expression rates of GPC-3,CD147 and CD10 in HCC tissues were significantly higher than those in adjacent tissues while the positive expression rate of CD138 in HCC tissues was significantly lower than that in adjacent tissues,the difference was statistically significant(P<0.05).The positive expression rates of GPC-3,CD147 and CD10 in high differentiation group were significantly lower than those in moderate or poor differentiation group while the positive expression rate of CD138 in high differentiation group was significantly higher than in moderate or poor differentiation group,the difference was statistically significant(P<0.05).Conclusion The expression levels of GPC-3,CD147,CD10 and CD138 may be related to the occurrence and development of HCC,and may be used as tumor markers to further guide the clinical diagnosis and identification of HCC.