糖尿病肾病维持性腹膜透析的单中心临床研究

A Single Center Retrospective Study on the Patients of Diabetic Kidney Disease Undergoing Maintenance Peritoneal Dialysis

目的总结糖尿病肾病(diabetic Kidney disease,DKD)维持性腹膜透析患者的相关数据,优化DKD患者的肾脏替代治疗方案。方法回顾性分析2012年1月至2017年12月南京中医药大学附属中西医结合医院进行维持性腹膜透析超过3个月的患者70例。根据原发病分为DKD组和Non-DKD组。观察两组的年龄、性别、实验室指标、生存率。结果DKD组1年生存率94.1%,3年生存率72.4%,4年生存率24.1%;Non-DKD组1年生存率97.3%,3年生存率89.2%,4年生存率81.8%,5年生存率61.3%,两组比较差异无统计学意义(P=0.051)。除纤维蛋白原(P=0.006)外,DKD组和Non-DKD组的临床指标差异均无统计学意义(P>0.05)。结论腹膜透析对DKD患者3年内生存率无影响,可以作为DKD肾脏替代治疗的初始方案之一。

Objective To summarize the data of patients with diabetic kidney disease(DKD)undergoing maintenance peritoneal dialysis and optimize the renal replacement treatment options for patients with DKD.Methods From January 2012 to December 2017,70 patients from Nanjing University of traditional Chinese Medicine Affiliated Hospital of traditional Chinese and Western medicine were selected for maintenance peritoneal dialysis for more than 3 months.Results The 1-,3-,and 4-year survival rate of DKD group was 94.1%,72.4%,24.1%respectively.The 1-,3-,and 4-year survival rate of Non-DKD group was 97.3%,89.2%,81.8%,61.3%respectively(P=0.051).Except the fibrinogen,there were no statistically significant differences between DKD group and Non-DKD group.Conclusion Peritoneal Dialysis was one of the initial options for DKD renal replacement therapy due to the result of the 3-year survival rate.