颈淋巴结转移率在53例甲状腺包裹型乳头状癌相关病理因素分析

Analysis of pathological factors associated with cervical lymph node metastasis in 53cases of encapsulated papillary thyroid carcinoma

目的探讨甲状腺包裹型乳头状癌的临床病理特征、淋巴结转移率及转移相关因素、治疗及预后。方法收集武汉大学人民医院病理科2015年9月至2018年12月53例甲状腺包裹型乳头状癌手术切除标本进行回顾性分析。结果53例甲状腺包裹型乳头状癌患者年龄20~73岁(平均44.2岁),男女比例为1:2.5,肿瘤直径0.1~3.2cm,肿瘤单侧好发,颈淋巴结转移率为13.2%,其中普通型乳头状癌颈淋巴结转移率明显高于乳头状微小癌(P<0.05),随访期间预后存活率100%。结论甲状腺包裹型乳头状癌是甲状腺乳头状癌的一种特殊亚型,颈淋巴结转移率与肿瘤大小密切相关,治疗以手术切除为主,预后相对较好。

Objective To investigate the clinicopathological features,lymph node metastasis rate as well as its related factors,treatment and prognosis of encapsulated papillary thyroid carcinoma(EPTC).Methods A retrospective analysis was performed on 53 surgically resected specimens of EPTC collected from September 2015 to December 2018 in the Department of Pathology,Renmin Hospital of Wuhan University.Results 53 patients with EPTC were 20-73 years old(mean age was 44.2 years);the ratio of male to female was 1:2.5;tumor diameter was 0.1-3.2cm;unilateral tumor was more common;cervical lymph node metastasis rate was 13.2%,among which the cervical lymph node metastasis rate of common papillary carcinoma was significantly higher than that of papillary micro-carcinoma(P<0.05),and the survival rate was 100%during follow-up.Conclusion EPTC is a special subtype of papillary thy-roid carcinoma.The rate of cervical lymph node metastasis is closely related to tumor size.The main treatment is surgical resection and the prognosis is relatively good.