微小RNA-140与骨关节炎关系的研究进展

Role of microRNA-140 in pathogenesis of osteoarthritis

骨关节炎是一种以关节软骨退变为主的退行性疾病,但其具体发病机制目前尚不清楚。微小RNA-140(miR-140)是一种在软骨细胞中特异性高表达的microRNA,为软骨细胞调控信号网络中重要的一员,参与了软骨细胞形成、增殖、分化、衰老及凋亡的调控作用。然而,由于miR-140作用的复杂性,其参与骨关节炎(OA)软骨退变的具体分子机制目前仍不明确。本文针对miR-140在软骨形成与稳态维持、软骨退变及OA早期诊断方面的作用进行综述。

Osteoarthritis is a degenerative diseases mainly in articular cartilage,but its pathogenesis has not been elucidated yet.MicroRNA-140(miR-140)is a specific and high expression microRNA in cartilage,which plays an essential role in chondrogenesis,proliferation,mature,differentiation,aging as well as apoptosis.However,due to its complex role,the molecular mechanism of miR-140 in the pathogenesis of osteoarthritis is unclear yet.Thus,this article reviewed recent literatures in order to discuss the role of miR-140 in chondorgenesis,cartilage homeostasis and degeneration as well as early diagnosis of osteoarthritis.