散结通脉方治疗稳定性心绞痛的临床研究

Treatment of Sanjie Tongmai Formula guided on the treatment of stable angina

目的探讨“瘀能化水”学术思想指导的散结通脉方对稳定性心绞痛痰瘀互结证的临床疗效及安全性。方法选取2018年7月—2019年4月期间的稳定性心绞痛患者72例,将符合条件的稳定性心绞痛患者随机分为治疗组和对照组,各36例,对照组采用西药标准化治疗,治疗组在对照组治疗的基础上加服具有清化痰浊、化瘀利水作用的散结通脉方,治疗4周,观察两组患者治疗前后心绞痛疗效,中医证候疗效及血脂四项(TC、TG、LDL-C、HDL-C)、超敏C反应蛋白(hs-CRP)情况。结果治疗后在心绞痛疗效方面,治疗组总有效率94.12%,对照组84.85%,治疗组优于对照组,差异有统计学意义(P<0.05);在中医证候疗效方面,治疗组总有效率97.06%,对照组66.67%,治疗组明显优于对照组,差异有统计学意义(P<0.01);在改善TC、TG、LDL-C、Hs-CRP等指标方面,治疗组均优于对照组,差异有统计学意义(P<0.05),且未见不良反应。结论“瘀能化水”学术思想指导的散结通脉方对稳定性心绞痛痰瘀互结证具有较好的临床疗效及安全性。

Objective To explore the clinical efficacy and safety of Sanjie Tongmai Formula guided by the thought of“stasis can be transformed into water”on the treatment of stable angina differentiated by combined phlegm and stasis.Methods A total of 72 patients with stable angina treated from July,2018 to April,2019 who met the inclusion criteria were included and randomized into a treatment group and a control group,with 36 cases in each group.The control group was given conventional treatment.The treatment group was given Sanjie Tongmai Formula(which can clear and transform phlegm-turbidity,resolve stasis and drain water)combined with conventional treatment.The treatment lasted for 4 weeks.The clinical efficacy,TCM syndrome score and cholesterol levels(TC,TG,LDL-C,HDL-C)and high-sensitivity C-reactive protein(hs-CRP)in both groups were observed after treatment.Results In treating angina,the total effective rate of the treatment group(94.12%)was significantly higher than that of the control group(84.85%),with statistical significance(P<0.05).In improving TCM syndrome,the total effective rate of the treatment group(97.06%)was significantly higher than that of the control group(66.67%),with statistical significance(P<0.05).In improving the cholesterol levels,the treatment group was more significant than the control group,with statistical significance(P<0.05).No adverse events were found.Conclusion The Sanjie Tongmai Formula guided by the thought of“stasis can be transformed into water”has a good clinical effect and safety in treating stable angina differentiated by combined phlegm and stasis.