摘要
白介素(IL) 12和IL 23是异源二聚体细胞因子,拥有共同的亚基p40,在固有免疫细胞和T细胞的分化和增殖方面均发挥重要的免疫学功能。大量研究显示IL 12/23在炎症性肠病的发病机制中扮演重要的作用。本文就抗IL 12/23单抗的作用机制及临床应用最新进展进行总结和阐述。
The heterodimeric cytokines IL 12 and IL 23,composed of a shared p40 subunit,play a key role in T helper cell and innate lymphocyte cell differentiation and expansion.Studies demonstrated that IL 12 and IL 23 played a pivotal role in inflammatory bowel disease.Here we review the immunological background to anti IL 12/IL 23 directed therapeutic strategies and latest research updates.
作者
陈旻湖
Chen Minhu(Department of Gastroenterology,The First Affiliated Hospital,Sun Yat sen University,Guangzhou 510080,China)
出处
《中华炎性肠病杂志（中英文）》
2020年第1期16-19,共4页
Chinese Journal of Inflammatory Bowel Diseases
