低剂量巴氯芬辅助治疗对三叉神经痛患者的疗效及对炎症因子、氧化应激反应的影响

Effects of low-dose baclofen adjuvant therapy on patients with trigeminal neuralgia and its effects on inflammatory factors and oxidative stress

目的:研究低剂量巴氯芬辅助治疗对三叉神经痛患者的疗效及对炎症因子、氧化应激反应的影响。方法:选择2017年1月到2019年1月在温州医科大学附属第一医院接受治疗的三叉神经痛患者112例为研究对象,按照随机数字表法分为试验组(n=56)和对照组(n=56)。对照组使用奥卡西平进行治疗,试验组在对照组的基础上采用低剂量巴氯芬辅助治疗,比较两组患者的临床总有效率、视觉模拟评分量表(VAS)评分、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)以及不良反应发生率水平。结果:试验组患者的临床总有效率明显高于对照组(P<0.05);两组患者的VAS评分明显低于治疗前(P<0.05),且试验组患者的VAS评分明显低于对照组(P<0.05);两组患者的TNF-α、IL-6水平明显低于治疗前(P<0.05),且试验组患者的TNF-α、IL-6水平明显低于对照组(P<0.05);两组患者的MDA水平明显低于治疗前(P<0.05),SOD、GSH-Px水平明显高于治疗前(P<0.05),且试验组患者的MDA水平明显低于对照组(P<0.05),SOD、GSH-Px水平明显高于对照组(P<0.05);两组患者不良反应发生率比较无统计学差异(P>0.05)。结论:低剂量巴氯芬辅助治疗对三叉神经痛患者具有较好的临床疗效,能有效缓解患者疼痛,改善患者炎症反应及氧化应激反应。

AIM:To study the effect of low-dose baclofen on inflammatory factors and oxidative stress in patients with trigeminal neuralgia.METHODS:A total of 112 patients with trigeminal neuralgia treated in our hospital from Jan.2017 to Jan.2019 were selected as the subjects;they were divided into test group(n=56)and control group(n=56)according to random number table method.The control group was treated with oxcarbazepine,while the test group was treated with low-dose baclofen on the basis of the control group;the clinical total effective rate,visual analogue scale(VAS),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),malondialdehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)levels and the incidence of adverse reactions were compared between the two groups.RESULTS:The clinical total effective rate of the test group was significantly higher than that of the control group(P<0.05);the VAS score of the two groups was significantly lower than that before treatment(P<0.05),and the VAS score of the test group was significantly lower than that of the control group(P<0.05);the levels of TNF-α,IL-6 and in the two groups were significantly lower than those before treatment(P<0.05),and the levels of TNF-α,IL-6 and in the test group were significantly lower than those in the control group(P<0.05);the levels of MDA in the two groups were significantly lower than those before treatment(P<0.05),SOD and GSH-Px were significantly higher than those before treatment(P<0.05),and the levels of MDA in the test group were significantly lower than those in the control group(P<0.05),while the levels of SOD and GSH-Px were significantly higher than those in the control group(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).CONCLUSION:Low-dose baclofen adjuvant therapy has good clinical efficacy for patients with trigeminal neuralgia,which can effectively relieve pain,reduce inflammation and oxidative stress.