miR-221/222与肿瘤发生发展关系的研究进展

Research progress on the relationship between miR-221/222 and tumorigenesis and development

微小RNA-221/222(miR-221/222)是一类与肿瘤发生密切相关的微小RNA,异常表达存在于机体多系统、多步骤、多位点肿瘤的分化发展进程中。miR-221/222通过靶向不同靶基因的信号转导途径发挥着抑癌基因或促癌基因的作用,有望成为恶性肿瘤的生物学标志物和新型治疗靶点。该文就miR-221/222与肿瘤发生发展关系的研究进展作一综述。

Micro ribonucleic acid-221/222(miR-221/222)is a kind of microRNAs closely related to tumorigenesis.Abnormal expression of miR-221/222 exists in the process of differentiation and development of multi-system,multi-step and multi-site tumors.MicroRNA-221/222 plays the role of tumor suppressor or oncogene through signal transduction pathway targeting different target genes,and is expected to become a biomarker and a novel therapeutic target for malignant tumors.In this paper,we review the research progress on the relationship between miR-221/222 and tumorigenesis and development.