瑞舒伐他汀联合缬沙坦对血压及脉压作用的观察

Observation on the effects of Rosuvastatin combined with valsartan on blood pressure and pulse pressure

目的探讨瑞舒伐他汀联合缬沙坦对血压及脉压的作用。方法选取2016年1月—2017年6月我院收治的60例高血压合并高脂血症患者,依据随机数字表法分为2组,各30例。对照组予以缬沙坦胶囊治疗,观察组于对照组基础上加用瑞舒伐他汀钙片,对比2组治疗前、治疗4周后、治疗8周后、治疗24周后血压指标及临床疗效。结果2组治疗前、治疗4周后SBP、DBP及PP比较,差异无统计学意义(P>0.05);治疗8周、24周后,观察组SBP、DBP及PP均低于对照组,差异有统计学意义(P<0.05)。2组治疗4周后总有效率无显著差异(P>0.05);观察组治疗8周后及24周后总有效率均高于对照组,差异有统计学意义(P<0.05)。结论瑞舒伐他汀联合缬沙坦治疗高血压合并高脂血症患者效果良好,可有效提升临床疗效,降低患者血压与脉压,改善预后,值得临床推广。

Objective To investigate the effects of rosuvastatin combined with valsartan on blood pressure and pulse pressure.Methods Sixty patients with hypertension and hyperlipidemia admitted in our hospital from January 2016 to June 2017 were selected and divided into two groups according to the random number table method,30 cases each.The control group was treated with valsartan capsules and observed In the group,rosuvastatin calcium tablets were added to the control group.The blood pressure and pulse pressure indexes and clinical efficacy of the two groups were compared before treatment,4 weeks after treatment,8 weeks after treatment,and 24 weeks after treatment.Results There was no significant difference in SBP,DBP and PP between the two groups before and after 4 weeks of treatment(P>0.05).After 8 weeks and 24 weeks of treatment,SBP,DBP and PP in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).There was no significant difference in the total effective rate between the two groups after 4 weeks of treatment(P>0.05).The total effective rate of the observation group after 8 weeks and 24 weeks was higher than that of the control group,with statistically significant difference(P<0.05).Conclusion Rosuvastatin combined with valsartan has a good effect on patients with hypertension and hyperlipidemia,and can effectively improve clinical efficacy,reduce blood pressure and pulse pressure,improve patient prognosis,and is worthy of clinical promotion.