流感病毒及其疫苗接种对慢性心力衰竭患者病情与结局影响研究进展

Progress in researches on effects of influenza virus and its vaccination on condition and outcome of patients with chronic heart failure

流感病毒感染可导致慢性心力衰竭(CHF)患者病情发生恶化,疾病负担明显高于普通人群,接种流感疫苗可降低CHF患者住院和死亡风险,改善疾病预后。本文从流感病毒感染对CHF患者病情进展的影响、流感疫苗接种对CHF患者病情进展与结局的影响及其病理生理机制方面进行综述,旨在为进一步提高中国公众和卫生保健人员对CHF患者接种流感疫苗的认识,为后续开展CHF患者接种流感疫苗的相关研究提供参考。

Influenza virus infection can lead to the deterioration of chronic heart failure(CHF) patients and the disease burden is significantly higher than that of the general population. Influenza vaccination can reduce the risk of hospitalization and death of CHF patients and improve the prognosis of the disease. This article reviews the effects of influenza virus infection on the progression of CHF, the effects of influenza vaccination on the progression and outcome of CHF patients,and their pathophysiological mechanisms. The aim of the study is to further improve the awareness of the public and health care personnel in China on the vaccination of CHF patients, and to provide references for future researches on the vaccination of CHF patients.