单活泼氢手性配体生成的原位镁催化剂及其在不对称合成中的应用

The in-situ Magnesium Catalysts Generated by Mono-Active Hydrogen Containing Ligands and their Applications in Asymmetric Synthesis

本文对原位镁催化剂近年的工作进行了总结,对由单活泼氢手性配体生成的原位镁催化剂在不对称合成中的应用进行了系统归纳和分类。介绍了由单氮氢键、单酚羟基和单醇羟基构成的手性配体的设计和发展及其在原位镁催化剂中的应用,实现了多种类型的不对称催化反应过程和化学键的形成方式。对于原位镁催化策略的进一步探索,将有助于研究和推广更多类型廉价环保金属资源催化的化学转化过程。

This review summarized the recent works on in-situ generated magnesium catalysts, especially for the systematic induction and category of in-situ magnesium catalysts generated from mono-active hydrogen containing ligands. We try to introduce the design and development of chiral ligands with mono-nitrogen-hydrogen bond, mono-phenol and mono-alcohol, and the related applications in in-situ generated magnesium catalysts, for realizing multi-types of asymmetric catalyzed transformations and the ways of chemical bonds formation. Further exploration of the strategy of in-situ generated magnesium catalysis would be beneficial to study and expand more types of chemical transformations mediated by cheap and low pollution metal resources.