C2轴手性硫脲的合成及其微波辅助下催化Biginelli反应性能

Syntheses of C2 Axial Chiral Thioureas and Their Microwave-Assisted Catalytic Performance for Biginelli Reaction

本文合成了三种具有轴手性联芳基骨架的多手性中心、多氢键的结构对称型多活性中心硫脲催化剂,并将其应用于催化Biginelli反应合成3,4-二氢嘧啶硫酮。结果表明,所合成的新型轴手性硫脲均表现出良好的催化作用,能有效地提高Biginelli反应的收率和对映选择性。

Three kinds of structure-symmetric thiourea catalysts with multi-chiral center and multi-hydrogen bond with axial chiral amphiyl skeleton were synthesized and applied to the synthesis of 3,4-dihydropyrimidine thioneone by Biginelli reaction. The results show that the synthesized axial chiral thioureas all show good catalytic activity, which can effectively improve the yield and enantioselectivity of the Biginelli reaction.