社区阿尔茨海默病患者生活质量现状的系统评价

A systematic review of the status of quality of life for Alzheimer's patients in the community

目的了解社区阿尔茨海默病(AD)患者生活质量现状及影响因素。方法参照Cochrane协作网工作手册检索PubMed、Scopus、EMbase、Web of Science、中国知网、万方、维普和中国生物医学文献数据库,纳入有关社区AD患者生活质量现状的横断面研究,由两名研究者独立进行文献筛选和质量评价,在提取资料后进行描述性分析。结果共纳入10篇文献,1721例患者。AD患者生活质量得分处于一般水平,AD生命质量量表测评结果显示,患者自评和照顾者代评总合并效应值分别为(35.27±4.08)分、(30.56±3.66)分,轻至中度患者合并效应值分别(35.47±6.03)分、(33.35±5.91)分,中至重度患者合并效应值分别(35.8±2.67)分、(30.33±2.26)分,患者自评得分明显高于照顾者代评得分。AD相关性生命质量量表测评结果显示,照顾者代评合并效应值为(66.95±13.03)分。影响AD患者生活质量的因素包括患者的年龄、性别、受教育程度、婚姻状况、居住方式、认知功能、精神行为症状、日常生活活动能力、疾病严重程度、药物的使用以及照顾者的年龄、性别、与患者的关系、身心健康状况、照顾负担等。结论社区AD患者的生活质量处于一般水平,影响其生活质量的因素较多,应针对可干预的影响因素进行有效干预。结论AD患者的生活质量处于一般水平,影响其生活质量的因素众多,我国AD患者生活质量现状及综合护理干预的研究有待加强。

Objective To understand the quality of life for patients with Alzheimer's disease(AD)in community and it’s influencing factors.Methods PubMed,Scopus,EMbase,Web of Science,CNKI,Wanfang,VIP,CBM were retrieved by referring to the Cochrane Collaborative Network Work Manual.The cross-sectional studies on the quality of life of AD patients in communities were included.Two researchers independently screened and evaluated the literature.Descriptive analysis was conducted after data collection.Results A total of 10 articles and 1721 patients were included.The scores of AD patients'qualof Alzheimer's disease quality of life scale showed that the total combined effect values of patients'self-assessment and caregiver's assessment were 35.27±4.08,30.56±3.66,35.47±6.03,33.35±5.91 for mild to moderate patients,and 35.35±5.91for moderate to severe patients respectively.The self-assessment score of patients was significantly higher than that of caregivers.The combined effect of caregivers'assessment was 66.95±13.03 according to the Alzheimer's disease-related quality of life scale.Factors that affect the quality of life in patients with AD include patients'age,gender,education level,marital status,living ways,cognitive function and mental symptoms,daily life activities ability,the severity of disease,drug use and caregivers of patients with age,sex,and relationships,physical and mental health,care burden,self-health status,care burden,depression and so on.Conclusion The quality of life of AD patients is at a general level.There are many factors affecting the quality of life of AD patients.The current situation of quality of life of AD patients in China.The study of comprehensive nursing intervention need to be strengthened.