丁苯酞序贯治疗对急性脑梗死患者神经功能及血清同型半胱氨酸和超敏C反应蛋白的影响

Effects of Sequential Butylphthalide Therapy on Neurological Function and Serum Homocysteine and Hypersensitive C-reactive Protein Levels in Patients with Acute Cerebral Infarction

目的 探讨在常规治疗基础上联合应用丁苯酞序贯治疗急性脑梗死患者,对其神经功能及血清超敏C反应蛋白和同型半胱氨酸水平的影响.方法 选取2018年6月-2019年3月大连市中心医院收治的58例急性脑梗死患者为研究对象,按随机数字表法分为观察组和对照组各29例.两组均给予阿托伐他汀、阿司匹林等常规治疗,观察组同时给予丁苯酞序贯治疗.比较两组治疗3个月后的神经功能、血清超敏C反应蛋白和同型半胱氨酸水平.结果 治疗3个月后两组神经功能均较治疗前得到改善,且观察组神经功能评分低于对照组,差异有统计学意义(P<0.05).治疗3个月后对照组血清同型半胱氨酸和超敏C反应蛋白水平与治疗前相比无改变,而观察组两项指标均较治疗前降低,两组治疗3个月后两项指标差异有统计学意义(P<0.05).结论 在常规治疗基础上联合丁苯酞序贯治疗急性脑梗死患者,能够有效改善患者的神经功能,而且能够使患者血清超敏C反应蛋白和同型半胱氨酸水平降低.

Objective To explore the effect of sequential application of butylphthal ide on neurological function and serum levels of hyperscnsitive C-reactive protein and homocysteine in patients with acute cerebral infarction on the basis of routinc treatment.Methods A total of 58 patients with acute cerebral infarction in our hospital from June 2018 to March 2019 were randomly divided into two groups.The control group was treated with aspirin and atorvastatin.On the basis of routine treatment,the treatment group was treated with butylphthal ide sequential therapy.Both groups were treated for 3 months.The neurological function.HCY and CRP were observed and compared before and after treatment between two groups.Results The neurological function in both groups significantly improved After 3 months treatment,while NIHSS score in treatment group was significantly lower than the control group(P<0.05).There was no significant differenee in HCY and CRP betore and after treatment in control group(P>0.05),but HCY and CRP were significantly decreased after 3 months treatment in treatment group.Conclusion On the basis of routine treatment,sequential treatment with butylphthalide in patients with acute cerebral infarction can improve their neurological function and reduce the serum levels of hypersensitive C-reactive protein and homocysteine.