奥曲肽两种给药方式治疗轻症急性胰腺炎的效果比较

Comparison of Two Routine Administration Methods of Octreotide in the Treatment of Mild Acute Pancreatitis

目的 比较奥曲肽常规静脉滴注和微泵注射治疗轻症急性胰腺炎的临床效果.方法 收集中国人民解放军北部战区总医院2018年6月-2019年6月收治的轻症急性胰腺炎患者120例,随机分为常规组和微泵组各60例.两组均接受常规基础治疗,奥曲肽给药方式常规组为静脉滴注、微泵组为微泵注射.比较两组治疗后症状缓解时间、炎症因子水平和不良反应发生情况.结果 微泵组腹胀、腹痛、体温、进食、血淀粉酶缓解或恢复正常时间均短于常规组,各炎症因子水平均低于常规组,差异均有统计学意义(P<0.05).两组各项不良反应发生情况差异均无统计学意义(P>0.05).结论 奥曲肽微泵注射途径给药治疗轻症急性胰腺炎的效果优于静脉滴注给药,值得推广使用.

Objective To compare the clinical efleets of octreotide intravenous injection and micropump injection in the treatment of mild acute pancreatitis(MAP).Methods A total of 120 patients with acute pancreatitis admitted to our hospital from Jun 2018 to Jun 2019 were randomly divided into routine group and micropump group with 60 cases in each group.Based on basic treatment,the routine group received octreotide intravenous injection,and the micropump group adopted micropump injection.The symptoms relief time,levels of inflammatory factors and adverse effects were compared between the two groups after treatment.Results The time of abdominal distension relief,abdominal pain relief,temperature recovery,diet recovery and blood amylase back to normal in the micropump group were significantly shorter than those in the routinc group(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion The effect of octreotide micropump injection in the treatment of MAP is better than that of traditional intravenous therapy,deserving to clinical application.