甘肃省首起新型冠状病毒肺炎非家庭聚集性疫情分析

Analysis of the first non-familial cluster of patients with coronavirus disease 2019 in Gansu

目的探讨甘肃省首起的新型冠状病毒肺炎(简称新冠肺炎)的非家庭聚集性疫情特征。方法回顾性分析甘肃省首起新冠肺炎非家庭聚集性疫情中6例患者的流行病学史及临床、影像特征。结果本组病例均为甘肃某幼儿园职工,年龄26~51岁,均为女性。患者同期赴泰国旅游,具有相同的流行病学暴露史。返回甘肃后在不同的时间点发病,均行咽拭子实时荧光定量反转录-PCR检测SARS-CoV-2核酸确诊,胸部CT显示典型的新冠肺炎影像学表现。首例确诊患者于2020年1月21日起病,首发症状为发热,曾就诊于兰州市西固区人民医院,经确诊后转至兰州市肺科医院经抗病毒治疗后痊愈出院。其余5例均就诊于甘肃省陇西县人民医院,主要临床症状为发热、咽喉部不适、头痛、乏力,经治疗后均痊愈出院。此次聚集性发病为甘肃首起泰国旅游后聚集性爆发,疾病程度为普通型,预后好。结论对于具有相同流行病学史的非家庭聚集性发病患者,尽早安排集中医学观察、SARS-CoV-2核酸检查、完善胸部CT评估病情后安排针对性治疗可获得良好的预后。

Objective To investigate the epidemiological characteristics of the first cluster of patients with coronavirus diseases 2019(COVID-19) in Gansu. Methods All 6 COVID-19 patients from a non-familial cluster in Gansu, were extracted from Gansu Provincial Health Information System until Feb 20, 2020. The patients were confirmed by nucleic acid detection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). The analyses were included via retrospective method: patient clinical characteristics, the summary of epidemiology, and CT image characteristics.Results This clustered outbreak was the first non-family clustered outbreak in Gansu after traveled to Thailand. All 6 COVID-19 confirmed patients were a kindergarten staff in Gansu, aged from 26 to 51 years, and were female. They traveled to Thailand in the same period, and had the same epidemiological exposure history. They were diagnosed as COVID-19 by transnasopharyngeal swab real-time fluorescent reverse transcription-PCR for SARS-CoV-2 nucleic acid examination at different time points after return to Gansu. The first patient was ill on January 21, 2020, with fever as first symptom. She was diagnosed at the Xigu District People’s Hospital in Lanzhou and was transferred to Lanzhou Pulmonary Hospital after being diagnosed. She was cured with one week’s antiviral treatment. The remaining5 patients were treated in Longxi People’s Hospital. The common clinical symptoms were fever, throat discomfort,headache, and fatigue. Through 7 to 10 days’ antiviral treatment, they all were cured. All patients belonged to common type and had good prognosis. Conclusion The COVID-19 patients in a non-familial cluster have the same epidemiological history. Early medical observation, SARS-CoV-2 nucleic acid examination and comprehensive chest CT should be arranged promptly to make diagnosis and give responsive treatment, so that the prognosis is often good.