慢性阻塞性肺疾病动物模型的造模方法

Methods for animal models of chronic obstructive pulmonary disease

慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD,以下简称为慢阻肺)是一种气道炎症性疾病,具有较高的发病率及病死率,给患者及社会带来沉重负担,目前对其发病机制及治疗方法仍未研究透彻。尽管动物模型仅能模拟疾病的部分特征,但它们对于进行慢阻肺生理病理、治疗的进一步研究是不可或缺的。本文结合PubMed收录的近三年慢阻肺造模相关文献,总结慢阻肺动物模型的模型动物种类、造模方法及测量指标。

Chronic obstructive pulmonary disease( COPD) is a kind of airway inflammatory disease,which has a high morbidity and mortality,and brings heavy burden to patients and society. And its pathogenesis and treatment methods have not been thoroughly studied at present. Although animal models can only simulate part of the characteristics of the disease,they are indispensable for further research on the physiology,pathology and treatment of COPD. This paper summarizes the animal models,modeling methods and measurement indexes of animal models of COPD in combination with the literatures relevant to COPD modeling in recent three years in PubMed.