造血干细胞移植后患者肠外营养管理的证据总结

Evidence summary: management of parenteral nutrition in patients undergoing hematopoietic stem cell transplantation

目的评价并总结造血干细胞移植后患者肠外营养管理的最佳证据,为临床干预提供方案。方法计算机检索JBI循证护理数据库、英国卫生医疗质量标准署数据库、美国国立指南库、Cochrane图书馆、PubMed、中国知网、万方数据库的相关指南、证据总结、专家共识等,按文献质量评价原则和标准提取证据。结果共纳入6篇文献,其中证据总结1篇,指南2篇,系统评价1篇、专家共识2篇。纳入最佳证据14条,包括肠外营养评估、预防外渗及导管并发症、预防代谢异常及标签管理4个方面。结论总结的最佳证据可用于造血干细胞移植后患者肠外营养管理;临床应用过程中宜根据当时情形针对性地选择证据,以保障适用、安全。

Objective To evaluate and summarize the best evidence for management of parenteral nutrition after hematopoietic stem cell transplantation(HSCT),and to provide protocol for clinical intervention.Methods We searched the JBI Database of Systematic Reviews,National Institute for Health and Clinical Excellence,National Guideline Clearinghouse(NGC),Cochrance Library,PubMed,CNKI,Wanfang database to collect guideline,evidence summary,and expert consensus,etc.Then evidence was summarized after quality evaluation of the literature.Results One evidence summary,two clinical practice guidelines,one systematic review,and two expert consensus statements were included.Fourteen pieces of evidence were summarized,including 4 aspects:parenteral nutrition assessment,prevention of extravasation and catheter-associated complications,prevention of metabolic abnormalities and label management.Conclusion The best evidence summarized in this study can be applied in management of parenteral nutrition in patients undergoing HSCT.It is recommended to use the evidence in clinical practice by considering clinical situation,thus to ensure its applicability and safety.