血常规中炎症指标对肝细胞肝癌预后的价值

Value of inflammatory index in blood routine on the prognosis of hepatocellular carcinoma

慢性炎症与肿瘤的发生发展,复发转移及免疫逃逸等关键环节有着深远的影响。而机体的炎症与免疫水平可以通过炎症反应的标志物反映,包括血液中的C反应蛋白、中性粒细胞、血小板、淋巴细胞以及它们的多种组合,如中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值、淋巴细胞与单核细胞比值、系统免疫炎症指数等。目前炎症指标已经在多种恶性肿瘤中被证实是复发和生存的预测因子。肝细胞肝癌(HCC)作为一种常见的侵袭性肿瘤,常在病程较晚时期才被诊断,因此患者往往不能取得满意的预后。本文主要对上述炎症反应指标在HCC中的临床应用进行综述。

Chronic inflammation and tumor occurrence and development,recurrence and metastasis and immune escape and other key links have a far-reaching impact.The level of inflammation and immunity can be reflected by the markers of inflammatory response,including C-reactive protein,neutrophils,platelets,lymphocytes and their combinations in the blood,such as neutrophil to lymphocyte ratio,platelet to lymphocyte ratio,lymphocyte to monocyte ratio,systemic immune inflammation index and so on.At present,inflammatory index has been proved to be predictors of recurrence and survival in a variety of malignant tumors.Hepatocellular carcinoma(HCC),as a common invasive tumor,is often diagnosed in the late course of the disease,so patients often can not achieve a satisfactory prognosis.This article mainly reviews the clinical application of the above inflammatory response indexes in HCC.