内关穴注射维生素B1治疗妊娠剧吐效果的meta分析及试验序贯分析

Meta-analysis and sequential analysis of the efficacy of vitamin B1 injection in treating hyperemesis gravidarum nèiguan point(P6)

目的meta分析及试验序贯分析评价内关穴注射维生素B1治疗妊娠剧吐的效果。方法对PubMed、Embase、Cochrane Library、中国生物医学文献数据库、中国期刊全文数据库、万方数据库、维普全文数据库进行检索。检索时间均为建库至2019年10月,检索策略为研究对象(P)+干预措施(I)+研究设计(S),主题词、自由词相结合。文献由2名通过培训的研究人员按照纳入和排除标准进行筛选。观察并记录文献基本特征及发表偏倚,采用RevMan5.3软件及Stata12.0软件进行meta分析及试验序贯分析。结果共纳入12篇文献,研究对象1247例。meta分析结果显示,试验组治疗妊娠剧吐有效率高于对照组,差异有高度统计学意义(OR=9.21,95%CI:4.87~17.43,P<0.01)。试验序贯分析进一步肯定内关穴注射维生素B1的治疗效果。结论内关穴注射维生素B1治疗妊娠剧吐止吐效果更明显,操作简单,但因本文的研究限制可能对结果产生偏倚,在临床推广应用时也需谨慎。

Objective To study the efficacy of vitamin B1 injection at nèiguan point(P6)for hyperemesis gravidarum was evaluated by meta-analysis and sequential analysis.Methods PubMed,Embase,Cochrane Library,CMB,CNKI,WanFang and VIP datebases were searched.The retrieval time was from the database establishment to October 2019.The retrieval strategy was research object(P)+intervention measures(I)+research design(S),with the combination of subject words and free words.The literature was screened by 2 trained researchers according to the inclusion and exclusion criteria.The basic characteristics and publication deviation of the literature were observed and recorded.The meta-analysis and sequential analysis of the experiment were carried out with RevMan 5.3 software and Stata12.0 software.Results A total of 12 articles and 1247 cases were included.Meta-analysis showed that effective rate of hyperemesis gravidarum in the experimental group was higher than that in the control group,and the difference was highly statistically significant(OR=9.21,95%CI:4.87-17.43,P<0.01).The effect of injection of vitamin B1 in nèiguan point(P6)was confirmed by sequential-analysis.Conclusion Injection of vitamin B1 into nèiguan point(P6)has a more obvious effect on the treatment of hyperemesis gravidarum and is easy to operate.However,due to the limitation of this study,the results may be biased,so it is necessary to be cautious in clinical application.