基于肠道微生态探索“调肝理脾”法治疗酒精性肝病的新思路

Exploration on the new idea of“regulating liver and spleen”in the treatment of alcoholic liver disease based on intestinal microecology

近年来我国酒精性肝病(ALD)的发病率正以惊人的速度上升,已经成为国内外学者研究的焦点问题之一。不少研究表明习惯性长期饮酒会引起肠道菌群失调,已经证实肠道菌群失调在肝脏疾病发生、发展中的核心作用。以改善肠道微生态失衡为切入点的治疗有望成为ALD新的治疗契机。“调肝理脾”法治疗ALD在长期临床实践及前期研究中被证实可有效解除酒精对肝脏的损伤,保护肝细胞,减轻肝纤维化程度,但作用机制尚未被完全阐明。因此,本文从肠道微生态角度系统阐述了“调肝理脾”法治疗ALD的现代理论学基础,并在前期研究基础上,探索“调肝理脾”法治疗ALD的效应机制,以期找到治疗ALD新的思路和研究方向。

In recent years,the incidence of alcoholic liver disease(ALD)in China is increasing at an alarming rate,which has become one of the focuses of domestic and foreign scholars.Many studies have shown that habitual long-term drinking can cause intestinal microecological imbalance.It has been confirmed that intestinal microecological imbalance plays a central role in the occurrence and development of liver diseases.Treatment of intestinal microecological imbalance is expected to be a new treatment opportunity for ALD.“Regulating liver and spleen”therapy for ALD has been proved to be effective in relieving alcohol-induced liver injury,protecting hepatocytes and alleviating liver fibrosis in long-term clinical practice and previous studies,but its mechanism has not been fully elucidated.Therefore,from the perspective of intestinal microecology,this paper systematically expounds the modern theoretical basis of“regulating liver and spleen”in the treatment of ALD,and on the basis of previous studies,explores the effective mechanism of“regulating liver and spleen”in the treatment of ALD,with a view to find new ideas and research directions for the treatment of ALD.