高危型人乳头瘤病毒感染宫颈病变患者体质特点探析

Discussion on Physical Characteristics of Cervical Lesions Patients with High-risk Human Papillomavirus Infection

目的探究高危型人乳头瘤病毒(HR-HPV)感染的宫颈病变患者中医体质分布特点,分析其临床特征与体质类型的关系,为中医药防治HR-HPV感染导致的宫颈病变提供依据。方法采用流行病学研究方法,以问卷调查的方式收集135例HR-HPV感染的宫颈病变患者相关信息,进行体质判定,分析其体质分布特点及主要体质类型与宫颈病变程度、HR-HPV感染特点、年龄及p16抑癌蛋白表达强度的关系。结果HR-HPV感染的宫颈病变患者体质类型所占比例由高到低依次为湿热质、阳虚质、平和质、气虚质、气郁质、阴虚质、痰湿质、血瘀质、特禀质,差异有统计学意义(P<0.05)。不同体质类型患者的宫颈病变程度、HR-HPV感染特点、年龄、p16抑癌蛋白表达强度比较,差异有统计学意义(P<0.05)。结论HR-HPV感染的宫颈病变患者体质类型以湿热质、阳虚质为主,其体质类型与宫颈病变程度、HR-HPV感染特点、年龄、p16抑癌蛋白表达强度有关。

Objective To explore the characteristics of TCM constitution distribution in cervical lesions patients with high-risk human papillomavirus(HR-HPV)infection;To analyze the relationship between clinical characteristics and constitutional types;To provide evidence for the prevention and treatment of cervical lesions caused by HR-HPV infection in TCM.Methods Epidemiological methods was used;135 cases of cervical lesions with HR-HPV infection were collected by questionnaire survey;their constitution distribution characteristics and the relationship between the main constitution types and the grade of cervical lesions,the characteristics of HR-HPV infection,age and the expression intensity of p16 anti-cancer protein were analyzed.Results The constitutional types of cervical lesions patients infected with HR-HPV were damp-heat,yang-deficiency,peace,qi-deficiency,qi-depression,yin-deficiency,phlegm-dampness,blood stasis and specific endowment in order from high to low,with statistical significance(P<0.05).The degree of cervical lesions,the characteristics of HR-HPV infection,age and the expression of p16 anti-cancer protein of patients with different constitution were different,with statistical significance(P<0.05).Conclusion The constitutional types of cervical lesions infected by HR-HPV are mainly damp-heat and yang deficiency,which are related to the degree of cervical lesions,HR-HPV infection characteristics,age,and p16 anti-cancer protein expression intensity.