支原体感染对川崎病患儿血清炎症因子水平及冠状动脉损害的影响

The effects of mycoplasma infection on the serum inflammatory factors and the coronary artery lesions in children with Kawasaki disease

目的:分析肺炎支原体(MP)感染对川崎病(KD)患儿血清炎症因子水平及冠状动脉损害(CAL)的影响。方法:根据是否合并MP感染,将102例KD患儿分为感染组(n=36)和未感染组(n=66)。对比分析两组患儿的年龄、性别、发热天数及入院时的主要临床症状、常规实验室检查。对两组患儿的血清白细胞介素-6(IL-6)、IL-8、IL-10、肿瘤坏死因子-α(TNF-α)水平进行检测和对比;观察比较两组患儿CAL发生率。结果:感染组患儿的白细胞计数和血小板计数高于未感染组(P<0.05);感染组患儿的血清IL-6、IL-8、IL-10、TNF-α水平均高于未感染组,差异均有统计学意义(P<0.05)。感染组患儿的CAL发生率高于未感染组(P<0.05)。结论:与未合并MP感染的患儿相比较,KD合并MP感染患儿的血清促炎因子表达明显上调,CAL发生率显著升高,MP感染介导的炎症反应加剧可能与CAL具有关联性。

Objective:To analyze the effects of Mycoplasma pneumoniae(MP)infection on the serum inflammatory factors and the coronary artery lesions(CAL)in children with Kawasaki disease(KD).Methods:102 children with KD were selected as the study subjects and divided into the infection group(n=36)and the uninfected group(n=66)according to whether they were combined with MP infection.The age,the gender,the fever days,the main clinical symptoms and the routine laboratory examination results between the subjects in the two groups were compared.The serum levels of IL-6,IL-8,IL-10 and tumor necrosis factor(TNF)-αwere measured and compared between the subjects in the two groups.The incidence of CAL was observed and compared between the subjects in the two groups.Results:The white blood cell count and the platelet count of the children in the infected group were higher than those of the uninfected group,the differences were statistically significant(P<0.05).The serum levels of IL-6,IL-8,IL-10 and TNF-αof the children in the infected group were higher than those in the uninfected group,the differences were statistically significant(P<0.05).The incidence of CAL of the children in the infected group was higher than that in the uninfected group,the difference was statistically significant(P<0.05).Conclusion:Compared with the children excluded of MP infection,the expressions of the serum pro-inflammatory factors in the children with KD complicated with MP infection were significantly up-regulated and the incidence of CAL increases significantly.The aggravation of inflammatory response mediated by MP infection may be related to CAL.