二仙汤辅助治疗绝经后女性高血压的临床效果及对雌激素和Kupperman评分的影响

Clinical effect of Erxian Decoction in adjuvant treatment of postmenopausal women with hypertension and its effect on estrogen and Kupperman score

目的探讨二仙汤辅助治疗绝经后女性高血压的临床效果及对雌激素和Kupperman评分的影响。方法采用随机对照的临床研究方法,选取2016年6月~2018年12月就诊于浙江省温州市中医院门诊和病房的绝经后女性高血压患者68例。根据随机数字表法分为两组,对照组(34例)采用贝那普利治疗,干预组(34例)在贝那普利治疗的基础上加用二仙汤。观察8周,记录两组治疗前后血压、雌激素水平、Kupperman评分,比较两组疗效。结果治疗后,两组收缩压和舒张压均较治疗前降低,且干预组显著低于对照组,差异有统计学意义(P<0.05)。治疗后,干预组的雌二醇水平均高于治疗前及对照组,差异有统计学意义(P<0.05);治疗后,干预组的卵泡刺激素水平均低于治疗前及对照组,差异有统计学意义(P<0.05)。治疗后,两组Kupperman评分均较治疗前降低,且干预组显著低于对照组,差异有统计学意义(P<0.05)。干预组治疗后总有效率高于对照组,差异有统计学意义(P<0.05)。结论二仙汤在贝那普利治疗的基础上能进一步降低绝经后女性高血压患者的收缩压和舒张压,也能调节雌激素水平,改善Kupperman评分。

Objective To investigate clinical effect of Erxian Decoction in adjuvant treatment of postmenopausal women with hypertension and its effect on estrogen and Kupperman score.Methods Randomized controlled clinical trial method was used,68 postmenopausal women with hypertension treated in outpatient and ward of Wenzhou Traditional Chinese Medicine Hospital from June 2016 to December 2018 were selected and divided into two groups with random number table,control group(34 cases)was treated with Benazepril,and intervention group(34 cases)was treated with Erxian Decoction on the basis of Benazepril.Observed for 8 weeks,blood pressure,estrogen levels,Kupperman scores of two groups before and after treatment were recorded and curative effect between two groups was compared.Results After treatment,systolic and diastolic blood pressure levels of two groups were lower than those before treatment,intervention group was significantly lower than control group,the differences were statistically significant(P<0.05).After treatment,estradiol level in intervention group was higher than that before treatment and in control group,the differences were statistically significant(P<0.05).After treatment,level of FSH in intervention group was lower than that before treatment and in control group,the difference was statistically significant(P<0.05).After treatment,Kupperman scores of two groups were lower than those before treatment,and intervention group was significantly lower than control group,the differences were statistically significant(P<0.05).Total effective rate of intervention group was higher than that of control group,the difference was statistically significant(P<0.05).Conclusion Erxian Decoction can further reduce systolic and diastolic blood pressure of postmenopausal women with hypertension on the basis of Benazepril treatment.It can also regulate estrogen level and improve Kupperman score.