2型糖尿病患者甲状腺激素与内脏脂肪面积的相关性分析

Association between thyroid hormones and visceral fat area in the patients with type 2 diabetes

目的探究2型糖尿病患者甲状腺激素与腹部内脏脂肪面积(visceral fat area,VFA)的相关性。方法收集2018年3月至2019年7月在宁波市第一医院纳入标准化代谢性疾病管理中心(National Metabolic Management Center,MMC)的729例2型糖尿病患者,测定甲状腺激素及生化指标,并应用生物电阻抗法测定VFA和皮下脂肪面积(subcutaneous fat area,SFA)。采用Spearman相关性分析和多元线性回归进行分析。结果Spearman相关性分析显示,T3、FT3与VFA呈正相关(r=0.225、0.211,P<0.01),FT4与VFA负相关(r=-0.112,P<0.01),而T4、TSH与VFA无相关性(均P>0.05)。多元线性回归分析显示,FT4、FT3与VFA有独立的相关关系(P<0.01),每增加1 pmol/L FT4,VFA减少1.759 cm^2,每增加1 pmol/L FT3,VFA增加3.256 cm^2。结论2型糖尿病患者的FT3、FT4与VFA相关。

Objective To explore the association between thyroid hormones and visceral fat area(VFA)in the patients with type 2 diabetes.Methods A total of 729 patients with type 2 diabetes,who joined National Metabolic Management Center(MMC)through Ningbo First Hospital from March,2018 to July,2019,were enrolled in this study.Blood tests were taken to assess their thyroid hormones and biochemical indexes.VFA and subcutaneous fat area(SFA)were obtained through bioelectrical impedance analysis.Statistics were later analyzed by Spearman correlation analysis and multivariate linear regression.Results Spearman correlation analysis showed that VFA were positively correlated with T3、FT3(r=0.225 and 0.211,P<0.01),and VFA were inversely correlated with FT4(r=-0.112,P<0.01).No correlation was found between VFA and either of T4 or TSH(P>0.05).Multivariate linear regression analysis indicated that VFA was independently correlated with FT4 and FT3(P<0.01).An increment of 1 pmol/L in FT4 was associated with 1.759 cm^2 increase in VFA,and increment of 1 pmol/L in FT3 was associated with 3.256 cm^2 decrease in VFA.Conclusion VFA in patients with type 2 diabetes are correlated with FT3 and FT4.