线粒体功能障碍在糖尿病并发症发病机制及治疗中的研究进展

The emerging role of mitochondrial dysfunction in the pathogenesis and treatment of diabetic complications

线粒体功能障碍在糖尿病并发症发病机制中发挥重要作用,并且靶向线粒体功能的治疗策略在此类疾病中也越来越受重视。本课题组长期致力于探寻线粒体氧化应激、能量代谢等线粒体功能失衡与多种糖尿病并发症的联系。本文就线粒体功能障碍在糖尿病溃疡、糖尿病肾病、糖尿病并发非酒精性脂肪肝发病机制中的作用及具体分子途径进行综述,并探讨靶向线粒体功能障碍治疗上述疾病的可行性。

Mitochondrial dysfunction plays an important role in the pathogenesis of diabetic complications,and more attention has been paid to the treatment strategies targeting mitochondrial function in these diseases.Our group has been devoted to exploring the relationship between mitochondrial dysfunction such as mitochondrial oxidative stress and energy metabolism,as well as various diabetic complications.This review highlighted recent progresses in the role of mitochondrial dysfunction in the pathogenesis of diabetic ulcer,diabetic nephropathy,diabetes complicated with nonalcoholic fatty liver and their correspondent molecular pathways,tried to explore the feasibility of targeting mitochondrial dysfunction in the treatment of these diseases.