摘要
目的评价云南省第一人民医院血液科2017年7月至2018年12月使用地西他滨(decitabine/Dacogen;DAC)方案和沙利度胺(thalidomide)+地塞米松(Dexamethasone,DXM)方案治疗骨髓增生异常综合征(MDS)中三种分型患者的疗效和不良反应。方法28例MDS患者,随机分二组,每组各14例,28 d为1周期,共4个疗程,完成方案后,进行观察结果比较。结果地西他滨方案和沙利度胺方案总有效率分别为92.85%、57.14%(P<0.01),部分及以上缓解率分别为64.28%、14.28%(P<0.01),其有效率、部分及以上缓解率明显高于沙利度胺方案(P<0.01)。在不良反应中地西他滨主要为骨髓抑制和诱发感染,而沙利度胺相对较轻,两组方案在骨髓抑制率和诱发感染率差异有统计学意义(P<0.05),其余不良反应两两比较无统计学意义(P>0.05)。结论与沙利度胺方案相比,地西他滨方案缓解率高、起效快、因其不良反应主要为骨髓抑制和诱发感染,应加强对症支持治疗。
Objective To evaluate the therapeutic effects and adverse reactions of Decitabine(Dacogen;DAC)and Thalidomide+Dexamethasone(DXM)in patients with Myelodysplastic Syndrome(MDS)admitted into the First People’s Hospital of Yunnan Province from 2017 to 2018.Methods Twenty-eight patients with MDS were randomly divided into two groups according to the drug regimen,14 patients in each group.Within a period of28 days,a total of 4 courses of treatment,observation and comparison between the two groups were made.Results Efficiency of Decitabine and Thalidomide was 92.85%and 57.14%,respectively(P<0.01).Partial and above remission rate of Decitabine was significantly higher than that of Thalidomide(64.28%and 14.28%,P<0.01).The adverse reactions of Decitabine were mainly bone marrow suppression and induced infection and were more severe than those of Thalidomide(P<0.05).There was no significant difference in other adverse reactions(P>0.05).Conclusions Decitabine has quicker effect and higher remission rates,but its adverse reactions are mainly bone marrow suppression and induced infection.Therefore,the treatment should be focused and supported.
作者
叶吉明
辜学忠
储雨妍
刘宇
叶吉云
YE Ji-ming;GU Xue-zhong;CHU Yu-yan;LU Yu;YE Ji-yun(Dept.of Pharmacy,the First People’s Hospital of Yunnan Province,Kunming Yunnan 650032;Dept.of Haematology,the First People’s Hospital of Yunnan Province,Kunming Yunnan 650032;Haiyuan College of Kunming Medical University,Kunming Yunnan 650040;School of Basic Medicines of Kunming Medical University,Kunming Yunnan 650500,China)
出处
《昆明医科大学学报》
CAS
2020年第3期72-76,共5页
Journal of Kunming Medical University
基金
云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2018FE001(-113)]。